Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

Hypoxia Drives Shared and Distinct Transcriptomic Changes in Two Invasive Glioma Stem Cell Lines

[Scientific Reports] Investigators surveyed eight patient-derived glioblastoma (GBM) stem cell lines for invasion phenotypes in 3D culture, which identified two GBM lines showing increased invasiveness in response to hypoxia.

Chronic Hypoxia Remodels the Tumor Microenvironment to Support Glioma Stem Cell Growth

[Acta Neuropathologica Communications] Researchers describe long-term cerebral organoids (COs) co-cultured with patient derived glioma stem cells (GSCs), a novel model in which COs were grown from embryonic stem cell cultures containing low levels of GSCs and tumor development wasmonitored over extended durations

DMRTA2 Supports Glioma Stem-Cell Mediated Neovascularization in Glioblastoma

[Cell Death & Disease] The authors showed the upregulation of DMRTA2 expression in malignant gliomas. Immunohistochemical staining showed the protein concentrated in small cells with high proliferative potential and cells localized around blood vessels, where it colocalized with pericyte-specific markers.

Exploiting Transcription Factors to Target EMT and Cancer Stem Cells for Tumor Modulation and Therapy

[Seminars In Cancer Biology] Understanding how transcription factors interact with their downstream targets for determining cell fate during embryogenesis and tumor development is a critical area of research.

LINC00115 Promotes Chemoresistant Breast Cancer Stem-Like Cell Stemness and Metastasis through SETDB1/PLK3/HIF1α Signaling

[Molecular Cancer] LncRNA microarray assay was performed to document abundance changes of lncRNAs in paclitaxel resistant MDA-MB-231 BCSC and non-BCSC. RNA pull-down and RNA immunoprecipitation assays were performed to determine the binding proteins of LINC00115.

Coordinated Activation of DNMT3a and TET2 in Cancer Stem Cell-Like Cells Initiates and Sustains Drug Resistance in Hepatocellular Carcinoma

[Cancer Cell International] Scientists addressed whether and how dysregulated epigenetic regulators have regulatory and functional communications in establishing and maintaining drug resistance.

89Zr-Labeled ImmunoPET Targeting the Cancer Stem Cell Antigen CD133 Using Fully-Human Antibody Constructs

[EJNMMI Research] Zirconium-89-radiolabeled immunoPET probes that target the cancer stem cell-antigen CD133 were developed using fully human antibody and antibody scFv-Fc scaffolds.

Exercise Affects High-Fat Diet-Stimulated Breast Cancer Metastasis through Irisin Secretion by Altering Cancer Stem Cell Properties

[Biochemistry And Biophysics Reports] Experimental metastasis was induced after eight weeks of steady exercise using a mouse model. Furthermore, one of the myokines, irisin, was studied to elucidate the effects of metastasis-regulating protein expression, and colony and sphere formation, which are cancer stem cell properties.

TMEM120B Strengthens Breast Cancer Cell Stemness and Accelerates Chemotherapy Resistance via β1-Integrin/FAK-TAZ-mTOR Signaling Axis by Binding to MYH9

[Breast Cancer Research] Investigators determined the role of TMEM120B in transcriptional coactivator with PDZ-binding motif-mediated CSC expansion and chemotherapy resistance.

Glioblastoma Stem Cell Metabolism and Immunity

[Cancer And Metastasis Reviews] The mechanisms by which glioma stem cells (GSCs) alter metabolic cues and escape elimination by immune cells are discussed, along with potential strategies to harness effector immune cells against GSCs.

Research Institute Announces New Research Theme Focusing on Kids with Cancer

[Global News] The Children’s Hospital Research Institute of Manitoba has announced its new research theme, which will focus on kids with cancer in support of the Children’s Hospital of Manitoba.

Single-Cell and Spatial Analyses Revealed the Co-Location of Cancer Stem Cells and SPP1+ Macrophage in Hypoxic Region That Determines the Poor Prognosis in Hepatocellular...

[NPJ Precision Oncology] The authors undertook a comprehensive study combining single-cell data and spatial data to obtain CSC signature and uncover its spatial structure.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.

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