Volume 2.39 | Oct 2

Cancer Stem Cell News 2.39 October 2, 2013
Cancer Stem Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Paracrine Activation of WNT/β-Catenin Pathway in Uterine Leiomyoma Stem Cells Promotes Tumor Growth
Investigators uncovered a paracrine role of the wingless-type (WNT)/β-catenin pathway that enables mature myometrial or leiomyoma cells to send mitogenic signals to neighboring tissue stem cells in response to estrogen and progesterone, leading to the growth of uterine leiomyomas. [Proc Natl Acad Sci USA] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem-Like Cells into S/G2/M-Phases
Investigators explored the use of a genetically engineered telomerase-specific oncolytic adenovirus, OBP-301 to mobilize the cell cycle and kill quiescent cancer stem-like cells. [Clin Cancer Res] Abstract

CD44 Expressed on CAFs Is a Functional Molecule Supporting the Stemness and Drug Resistance of Malignant Cancer Cells in the Tumor Microenvironment
Scientists showed that cancer-associated fibroblasts (CAFs) support tumor growth in vivo and maintain the stemness of cancer stem/initiating cells in an in vitro model using an established CAF cell line. [Stem Cells] Abstract

Inhibition of Monocarboxylate Transporter-4 Depletes Stem-Like Glioblastoma Cells and Inhibits HIF Transcriptional Response in a Lactate-Independent Manner
Researchers found that monocarboxylate transporter-4 (MCT4) knockdown was associated with a decreased percentage of glioblastoma cells expressing the stem-cell marker CD133 and increased apoptotic fraction. They also found that flow-sorted CD133-positive cells had almost sixfold higher MCT4 levels than CD133-negative cells, suggesting that the stem-like population might have a greater requirement for MCT4. [Oncogene] Abstract

Tumor Resident Mesenchymal Stromal Cells Endow Naïve Stromal Cells with Tumor-Promoting Properties
Using a mouse lymphoma model, scientists showed that lymphoma resident mesenchymal stem/stromal cells are able to confer tumor-promoting property to naïve cocultured bone marrow mesenchymal stem/stromal cells. [Oncogene] Abstract

In Vivo 5FU-Exposed Human Medullary Thyroid Carcinoma Cells Contain a Chemoresistant CD133+ Tumor-Initiating Cell Subset
Researchers investigated whether Glycoprotein Prominin-1 (CD133)+ cells derived from human medullary thyroid carcinoma possess tumor-initiating properties in vivo and exhibit differential responses to chemotherapeutic agents. [Thyroid] Abstract

Physiological Beta-Catenin Signaling Controls Self-Renewal Networks and Generation of Stem-Like Cells from Nasopharyngeal Carcinoma
HONE1 hybrid cells displayed stem cell-like properties, including enhancement of CD24+ and CD44+ populations and generation of spheres that were not observed in parental HONE1 cells. [BMC Cell Biol] Abstract | Full Article

miR-34 Is Associated with Poor Prognosis of Patients with Gallbladder Cancer through Regulating Telomere Length in Tumor Stem Cells
The miR34a level and telomere length were measured in 77 gallbladder adenocarcinomas and 36 peritumoral tissues by real-time PCR. Forced miR34a expression was established by an adenovirus carrying a miR34a expression cassette. The colony-forming ability of isolated CD44+CD133+ gallbladder cancer tumor stem-like cells was measured by matrigel colony assay. [Tumour Biol] Abstract

Isolation and Characterization of Squamous Cell Carcinoma-Derived Stem-Like Cells: Role in Tumor Formation
Since epithelial tumors originate from keratinocyte stem cells, investigators evaluated the features of rapidly adhering keratinocytes derived from primary human squamous cell carcinoma of the skin. [Int J Mol Sci] Abstract | Full Article

The Deubiquitinase USP28 Stabilizes LSD1 and Confers Stem-Cell-Like Traits to Breast Cancer Cells
Using an unbiased siRNA screening against all the human deubiquitinases, investigators identified USP28 as a bona fide deubiquitinase of LSD1. USP28 interacted with and stabilized LSD1 via deubiquitination. USP28 overexpression correlated with LSD1 upregulation in multiple cancer cell lines and breast tumor samples. [Cell Rep] Full Article | Graphical Abstract

NeuroCult™ for Brain Tumor Research - View Publications
 
REVIEWS
Molecular Insight in Gastric Cancer Induction: An Overview of Cancer Stemness Genes
This review analyzes and investigates the main genetic factors involved in tumorogenesis of gastric cancer and the molecular mechanism of their expression regulation alongside with the importance of cancer stem cells and their relationship with gastric cancer. [Cell Biochem Biophys] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

Stem Cell Society Singapore 2013 Symposium
 
INDUSTRY NEWS
National Cancer Institute Awards $48.6 Million Grant to MD Anderson
Broad, deep and outstanding research in cancer science, treatment and prevention have earned The University of Texas MD Anderson Cancer Center a $48.6-million, five-year grant from the National Cancer Institute and an “exceptional” ranking, the highest possible, from the National Cancer Institute’s extensive peer-review process. [The University of Texas MD Anderson Cancer Center] Press Release

Verastem Initiates Phase II Trial of Defactinib in Lung Cancer
Verastem, Inc. announced the initiation of a Phase II trial of defactinib (VS-6063), a potent inhibitor of focal adhesion kinase, in KRAS-mutated non-small cell lung cancer. [Verastem, Inc.] Press Release

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POLICY NEWS
US Government Shuts Down
The US government entered a state of suspended animation on 1 October after Congress failed to agree on a budget for the next fiscal year, causing federal agencies – including those overseeing science policy and research – to shut down indefinitely. Most government scientists were ordered to stay at home, their offices and labs closed or run by a skeleton staff of ‘essential’ workers. The National Institutes of Health and the National Science Foundation stopped processing grants, some government websites were made inaccessible and many important research programmes were left hanging, potentially putting lives at risk in the case of some disease studies. [Nature News] Editorial
 
EVENTS
NEW Cell Culture World Congress 2014
February 25-27, 2014
Munich, Germany

NEW 9th Annual World Stem Cells & Regenerative Medicine Congress 2014
May 20-22, 2014
London, United Kingdom

Visit our events page to see a complete list of events in the cancer stem cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Position – RNA & Stem Cell Biology (Cancer Research Centre of Lyon)

Postdoctoral Position – Breast Cancer Stem Cell Biology (UC College of Medicine)

Research Associate – Leukemia & Stem Cell Biology (King’s College London)

Tenure Track Faculty Positions – Cancer Biology (Memorial Sloan-Kettering Cancer Center)

Assistant Professor – Developmental and Stem Cell Biology (METU Department of Biology)

Principal Scientist – Cancer Stem Cells (Pharma Professionals Europe Ltd)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Technologist – Mesenchymal Cell Research (STEMCELL Technologies Inc.)

Research Technologist – Cell Culture Media & Matrices (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies Inc.)

Quality Control Analyst – Media (STEMCELL Technologies Inc.)


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