Cancer Stem Cell News

Cancer Stem Cell News is an online resource that curates the top research publications and reviews about cancer progenitor cells and cancer stem cells.

Interactions Between Cancer Cells and Immune Cells Drive Transitions to Mesenchymal-Like States in Glioblastoma

[Cancer Cell] Investigators dissected glioblastoma-to-microenvironment interactions by single-cell RNA sequencing analysis of human tumors and model systems, combined with functional experiments.

Butyrate Attenuates the Stemness of Lung Cancer Cells Through Lysosome Fe2+- and SLC7A11-Mediated Ferroptosis

[Heliyon] The authors constructed a series of in vitro experiments, including 3D non-adherent sphere-formation, cytometry analysis, assessment of CSC marker expression, cell migration assay, and in vivo tumorigenesis analyses.

Bio-Responsive Au-miR-183 Inhibitor Enhances Immunotherapy in Hepatocellular Carcinoma by Inducing Immunogenic Cell Death

[Journal Of Controlled Release] Scientists constructed a bio-responsive Au-miR-183 inhibitor delivery system targeting liver cancer stem cells, and adopted the strategy of combining αPD-L1 immunotherapy.

Activation of the PI3K/AKT Signaling Pathway by ARNTL2 Enhances Cellular Glycolysis and Sensitizes Pancreatic Adenocarcinoma to Erlotinib

[Molecular Cancer] Investigators examined the levels of various cancer hallmarks and identified glycolysis as the primary risk factor for overall survival in pancreatic cancer.

Epigenetic Control Over Cell-Intrinsic Immune Response Antagonizes Self-Renewal in Acute Myeloid Leukemia

[Blood] Researchers unveiled the histone demethylase PHF8 as a direct initiator and regulator of cell-intrinsic immune response in AML. Site-specific phosphorylation of PHF8 orchestrated epigenetic changes that upregulate cytosolic RNA sensors, particularly the TRIM25-RIG-I-IFIT5 axis, thereby triggering the cellular IFN-I response-differentiation-apoptosis network.

Inhibition of the AURKA/YAP1 Axis Is a Promising Therapeutic Option for Overcoming Cetuximab Resistance in Colorectal Cancer Stem Cells

[British Journal Of Cancer] The authors used transcriptomic analysis along with in vitro and in vivo models of RAS/RAF wild-type CRC to study YAP1 Ser397 phosphorylation as a potential biomarker for cetuximab resistance.

An Immunogenic Anti-Cancer Stem Cell Bi-Nuclear copper(II)-Flufenamic Acid Complex

[Dalton Transactions] The bi-nuclear copper(II) complex exhibited sub-micromolar potency towards breast CSCs grown in monolayers and three-dimensional cultures.

Targeting Metastasis-Initiating Cancer Stem Cells in Gastric Cancer with Leukemia Inhibitory Factor

[Cell Death Discovery] Leukemia inhibitory factor-treated gastric cancer cell lines, patient-derived xenograft cells and/or CSC tumourspheres underwent transcriptomics, laser microdissection-associated proteomics, 2D and 3D invasion assays and in vivo xenograft in mice blood circulation.

Ferroptosis in Cancer: From Molecular Mechanisms to Therapeutic Strategies

[Signal Transduction And Targeted Therapy] Scientists provide an overview of the recent advancements in understanding ferroptosis in cancer, covering molecular mechanisms, biological functions, regulatory pathways, and interactions with the tumor microenvironment.

Cancer Grand Challenges Selects Five New Global, Interdisciplinary Teams to Take On Four Challenges

[National Cancer Institute] Cancer Grand Challenges has selected five new global research teams that will address the following challenges in cancer: reducing cancer inequities, understanding the mechanisms of early-onset cancers, developing drugs for solid tumors in children, and broadening our knowledge about how T cells recognize cancer cells.

Exosomal lncRNA XIST Promotes Perineural Invasion of Pancreatic Cancer Cells via miR-211-5p/GDNF

[Oncogene] Scientists revealed that exosomal lncXIST derived from pancreatic cancer cells was delivered to neural cells and promoted their release of glial-cell-line-derived neurotrophic factor.

The Present and Future of Bispecific Antibodies for Cancer Therapy

[Nature Reviews Drug Discovery] Investigators provide an outlook into next-generation bispecific antibodies (bsAbs) in earlier stages of development, including trispecifics, bsAb prodrugs, bsAbs that induce degradation of tumour targets and bsAbs acting as cytokine mimetics.

Cancer Stem Cell News consolidates the most recent publications covering research areas such as the identification and isolation of cancer stem cells, their proliferation and differentiation characteristics, gene expression and regulatory pathways, and the development of anti-cancer therapies. We also include cancer stem cell jobs and events hosted by leading research organizations, societies, and institutes.

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