Volume 5.16 | Apr 27

Cancer Stem Cell News 5.16 April 27, 2016
Cancer Stem Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Researchers Find Potential New Treatment Target for Deadly Brain Cancer
A team of researchers has found a key player in brain tumor formation that may lead to new therapies for a deadly and incurable cancer. The study is the first to show that a protein called OSMR (oncostatin m receptor) is required for glioblastoma tumors to form. [Press release from the Ottawa Hospital Research Institute discussing online prepublication in Nature Neuroscience] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
All-Trans Retinoic Acid Synergizes with FLT3 Inhibition to Eliminate FLT3/ITD+ Leukemia Stem Cells In Vitro and In Vivo
Researchers explored the efficacy of combining all-trans retinoic acid (ATRA) and FLT3 tyrosine kinase inhibitors to eliminate FLT3/ITD+ leukemic stem cells. They revealed highly synergistic drug activity, preferentially inducing apoptosis in FLT3/ITD+ cell lines and patient samples. [Blood] Abstract

NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem–Like Cells in Adenoid Cystic Carcinoma
The authors isolated cancer stem cells (CSC) from adenoid cystic carcinoma and characterized them, they used ROCK inhibitor-supplemented cell culture, immunomagnetic cell sorting, and in vitro/in vivo assays for CSC viability and tumorigenicity. [Clin Cancer Res] Abstract | Press Release

Crosstalk between Bone Marrow-Derived Myofibroblasts and Gastric Cancer Cells Regulates Cancer Stemness and Promotes Tumorigenesis
Investigators found that co-injection of bone marrow-derived myofibroblasts (BMFs) with gastric cancer cells markedly promoted tumorigenesis. Co-cultured BMFs or BMF-conditioned medium induced the formation of spheres, which expressed stem cell signatures and exhibited features of self-renewal, epithelial-to-mesenchymal transition and tumor initiation. [Oncogene] Abstract

NOTCH1 Inhibition Enhances the Efficacy of Conventional Chemotherapeutic Agents by Targeting Head Neck Cancer Stem Cell
Scientists aimed to investigate the possibility of targeting head neck squamous cell carcinoma by NOTCH1 pathway inhibition and explore the synergistic effect of combining NOTCH inhibition with conventional chemotherapy. [Sci Rep] Full Article

Expression of Breast Cancer Stem Cell Markers as Predictors of Prognosis and Response to Trastuzumab in HER2-Positive Breast Cancer
The authors investigated the impact of breast cancer stem cells marker expression on clinical outcome and trastuzumab response in human epidermal growth factor receptor 2 (HER2)-positive breast cancer. [Br J Cancer] Abstract

Biomarker-Specific Conjugated Nanopolyplexes for the Active Coloring of Stem-Like Cancer Cells
Stem-like cancer cells possess intrinsic features and their CD44 regulate redox balance in cancer cells to survive under stress conditions. Thus, researchers have fabricated biomarker-specific conjugated polyplexes using CD44-targetable hyaluronic acid and redox-sensible polyaniline based on a nanoemulsion method. [Nanotechnology] Abstract

A Convenient and Effective Strategy for the Enrichment of Tumor-Initiating Cell Properties in Prostate Cancer Cells
For prostate cancer (PrCa) tumor-initiating cells (PrTICs) enrichment, scientists induced cancer stem cell (CSC) properties in PrCa cells by transducing three defined factors (OCT3/4, SOX2, and KLF4), followed by culture with conventional serum-containing medium. The CSC properties in the transduced cells were evaluated by proliferation, cell cycle, side population assay, drug sensitivity technology, in vivo tumorigenicity, and molecular marker analysis of PrCSCs compared with parental cells and spheroids. [Tumor Biol] Abstract

Ionizing Radiation Promotes Advanced Malignant Traits in Nasopharyngeal Carcinoma via Activation of Epithelial-Mesenchymal Transition and the Cancer Stem Cell Phenotype
Scientists investigated the malignant behaviors of post-irradiation residual nasopharyngeal carcinoma cells, to identify the potential underlying mechanisms and to search for appropriate bio-targets to overcome this malignancy. [Oncol Rep] Abstract | Full Article (Download)

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REVIEWS
To Wake Up Cancer Stem Cells, or to Let Them Sleep, that Is the Question
The reviewers address two opposite approaches to the therapeutic targeting of cancer stem cells (CSCs)-wake-up and hibernation therapies that either promote or prevent the entry of CSCs into the cell cycle, respectively, and they discuss the potential advantages and risks of each strategy. [Cancer Sci] Full Article

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.
 
INDUSTRY NEWS
Celsion Corporation Announces Enrollment of First Patient in the OPTIMA Study in China
Celsion Corporation announced that the first patient in China has been enrolled in its ongoing global Phase III OPTIMA Study evaluating ThermoDox®, Celsion’s proprietary heat-activated liposomal encapsulation of doxorubicin, in combination with radiofrequency ablation to treat newly diagnosed patients with primary liver cancer. [Celsion Corporation] Press Release

PerkinElmer and Genome Institute of Singapore Open Joint Research Laboratory to Advance Precision Oncology
PerkinElmer, Inc. and the Genome Institute of Singapore (GIS) announced the opening of the PerkinElmer-GIS Centre for Precision Oncology. Leaders from PerkinElmer and GIS attended the official opening ceremony and discussed objectives for the joint research laboratory. [PerkinElmer, Inc.] Press Release

Bristol-Myers Squibb’s Opdivo® (Nivolumab) Receives Breakthrough Therapy Designation
Bristol-Myers Squibb Company announced that the U.S. Food and Drug Administration has granted Breakthrough Therapy Designation to Opdivo for the potential indication of recurrent or metastatic squamous cell carcinoma of the head and neck after platinum based therapy. [Bristol-Myers Squibb Company] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Gordon Research Conference – Notch Signaling in Development, Regeneration & Disease
July 31-August 5, 2016
Lewiston, United States

Visit our events page to see a complete list of events in the cancer stem cell community.
 
JOB OPPORTUNITIES
NEW Group Leader – Various Projects (Monash University)

Senior Research Associate – Bioinformatics of Lung Cancer Evolution (University College London)

Full Professorship – Radiopharmaceutical Development (German Cancer Research Center)

Postdoctoral Fellow – Prostate Epithelial Homeostasis and Carcinogenesis (Baylor College of Medicine)

Senior Scientist – Immune-Oncology (PTM Biolabs Inc.)

Research Technician – Nutrition and Cancer (St. Anne’s University Hospital)

Postdoctoral Fellowship – Cancer Research (Universitat Pompeu Fabra)

Postdoctoral Fellow – Cancer Stem Cell Research (Fred Hutchinson Cancer Research Center)

Director – Cancer Genomics (Ontario Institute for Cancer Research)

Postdoctoral Fellow – Cancer Genomics (The Cancer Institute of New Jersey)

Postdoctoral Fellow – Breast and Ovarian Cancer (Johns Hopkins University School of Medicine)

Postdoctoral Fellow – Division of Cancer Biology (Case Western Reserve University)

Tenure Track Position – Cancer Biology (University of Texas MD Anderson Cancer Center)

Postdoctoral Fellowship – Various Projects (University of Cincinnati)

PhD Studentship – Peptide Receptors in Cancer Stem Cells (Exiris/Bielefeld University)

Faculty Position – Cancer Research (Various Areas) (The Jackson Laboratory)

Staff Scientist – Cell Therapy Process Development (Fred Hutchinson Cancer Research Center)


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