Volume 5.13 | Apr 6

Cancer Stem Cell News 5.13 April 6, 2016
Cancer Stem Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Interfacial Geometry Dictates Cancer Cell Tumorigenicity
By using engineered extracellular matrices, researchers showed that geometric features at the perimeter of tumor tissue will prime a population of cells with a stem-cell-like phenotype. [Nat Mater] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
CDKN2A-Independent Role of BMI1 in Promoting Growth and Survival of Ph+ Acute Lymphoblastic Leukemia
BMI1 is a key component of the polycomb repressive complex-1 required for maintenance of normal and cancer stem cells. The authors showed that BMI1 expression is important for proliferation and survival of Ph+ acute lymphoblastic leukemia cells and for leukemogenesis of Ph+ cells in vivo. [Leukemia] Abstract

Circulating Tumor Cells Exhibit Stem Cell Characteristics in an Orthotopic Mouse Model of Colorectal Cancer
The authors aimed to characterize colorectal cancer-derived circulating tumor cells (CTCs) to eventually identify the clinically relevant subfraction of CTCs. [Oncotarget] Full Article

Multifunctional Targeting Vinorelbine plus Tetrandrine Liposomes for Treating Brain Glioma along with Eliminating Glioma Stem Cells
Targeting conjugates of cholesterol polyethylene glycol polyethylenimine and D-a-tocopheryl polyethylene glycol 1000 succinate vapreotide were newly synthesized for transporting drugs across the blood-brain barrier and targeting glioma cells and glioma stem cells. [Oncotarget] Full Article

ASC-J9®, and Not Casodex or Enzalutamide, Suppresses Prostate Cancer Stem/Progenitor Cell Invasion via Altering the EZH2-STAT3 Signals
Researchers demonstrated that androgen deprivation therapy with anti-androgens Casodex and Enzalutamide, but not newly identified AR degradation enhancer ASC-J9®, increased prostate cancer (PCa) stem/progenitor population, which might then lead to enhanced PCa cell invasion. [Cancer Lett] Abstract

MicroRNA Profiling of Cisplatin-Resistant Oral Squamous Cell Carcinoma Cell Lines Enriched with Cancer-Stem-Cell-Like and Epithelial-Mesenchymal Transition-Type Features
Investigators aimed to identify the specific deregulated miRNAs which are responsible for development of resistance phenotype through regulating their resistance related target gene expression in oral squamous cell carcinoma. [Sci Rep] Full Article

Novel PKC-ζ to p47phox Interaction Is Necessary for Transformation from Blebbishields
Scientists demonstrated that a novel PKC-ζ to p47phox interaction is required for reactive oxygen species production in cancer cells. [Sci Rep] Full Article

CD55 Is a HIF-2α Marker with Anti-Adhesive and Pro-Invading Properties in Neuroblastoma
Scientists revealed that CD55 is a novel target of hypoxia-inducible factor HIF-2α in neuroblastoma (NB) cells. They showed that HIF-2α expression is sufficient to sustain stem-like features of NB cells, whereas CD55 protein upon HIF-2α expression contributes to growth of colonies and to invasion of cells, but not to stemness features. [Oncogenesis] Full Article

Glioma Stem Cells but Not Bulk Glioma Cells Upregulate IL-6 Secretion in Microglia/Brain Macrophages via Toll-Like Receptor 4 Signaling
Researchers explored the interaction between glioma stem cells (GSCs) and microglia/brain macrophages. Using CD133 as a marker of stemness, they enriched for or deprived the mouse glioma cell line GL261 of GSCs by fluorescence-activated cell sorting. [J Neuropathol Exp Neurol] Abstract

Hypoxia Regulates Stemness of Breast Cancer MDA-MB-231 Cells
The investigators cultured MDA-MB-231 cells in a hypoxic gas mixture to simulate the hypoxic environment in tissues and to determine how hypoxia conditions could affect the cell proliferation, apoptosis, cytotoxicity, and colony-forming ability. [Med Oncol] Full Article

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REVIEWS
Adoptive Transfer of Osteoclast-Expanded Natural Killer Cells for Immunotherapy Targeting Cancer Stem-Like Cells in Humanized Mice
The authors present current approaches, advances, and existing limitations in studying interactions of the immune system with the tumor, in particular natural killer cells with cancer stem-like cells, using in vivo preclinical humanized bone marrow, liver, thymus mouse model. [Cancer Immunol Immunother] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.
 
INDUSTRY NEWS
American Cancer Society Awards New Research and Training Grants
The American Cancer Society has approved funding for 103 research and training grants totaling nearly $44 million in the first of two grant cycles for 2016. [The American Cancer Society] Press Release

VUMC and Celgene Corporation Enter into Research Agreement to Accelerate Development of Next-Generation Therapeutics
Vanderbilt University Medical Center (VUMC) has entered into a strategic research agreement with Celgene Corporation. This collaboration will leverage BioVU, a DNA database linked to de-identified health information that includes 2.5 million clinical records and 215,000 genetic samples. [Vanderbilt University Medical Center] Press Release

$1.8 Million Supports Further Exploration of Drug Compound on Commonly Mutated Gene
Researcher and surgical oncologist Darren R. Carpizo, MD, PhD, has been awarded a $1,839,863 grant from the National Cancer Institute to build upon research from his laboratory examining a drug compound that restores tumor suppressor function in the most commonly mutated gene in human cancer – the p53 gene. [Rutgers Cancer Institute of New Jersey] Press Release

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POLICY NEWS
What New GSK Patent Policy Means for the Developing World
Public-health experts have applauded drug giant GlaxoSmithKline (GSK) for unveiling new patent policies that could make it easier for people in the world’s poorest countries to access drugs. But they say that other companies will need to follow suit if patients are to see significant improvements in access to medicines — particularly for much-needed cancer drugs. [Nature News] Editorial

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Mouse Development, Stem Cells & Cancer
July 8-28, 2016
Cold Spring Harbor, United States

Visit our events page to see a complete list of events in the cancer stem cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Fellow – Cancer Stem Cell Research (Fred Hutchinson Cancer Research Center)

Director – Cancer Genomics (Ontario Institute for Cancer Research)

Postdoctoral Fellow – Cancer Genomics (The Cancer Institute of New Jersey)

Postdoctoral Fellow – Breast and Ovarian Cancer (Johns Hopkins University School of Medicine)

Postdoctoral Fellow – Division of Cancer Biology (Case Western Reserve University)

Postdoctoral Fellowship – Statistical Methods in Cancer Progression (European Molecular Biology Laboratory)

Tenure Track Position – Cancer Biology (University of Texas MD Anderson Cancer Center)

Postdoctoral Fellowship – Various Projects (University of Cincinnati)

PhD Studentship – Peptide Receptors in Cancer Stem Cells (Exiris/Bielefeld University)

Postdoctoral Fellowship – Cancer Stem Cell Biology (McGill University Health Center)

Translational Research Scientist – Hematology and Oncology (University of Chicago)

Postdoctoral Fellowship – Cancer Stem Cell Biology (Fred Hutchinson Cancer Research Center)

PhD Studentship – Various Positions in Cancer (Virginia Commonwealth University)

Faculty Position – Cancer Research (Various Areas) (The Jackson Laboratory)

Faculty Position – Radioimmunotherapy (Fred Hutchinson Cancer Research Center)

Staff Scientist – Cell Therapy Process Development (Fred Hutchinson Cancer Research Center)


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