Volume 5.11 | Mar 23

Cancer Stem Cell News 5.11 March 23, 2016
Cancer Stem Cell News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY
The Role of Fas-Associated Phosphatase 1 in Leukemia Stem Cell-Persistence during Tyrosine Kinase Inhibitor-Treatment of Chronic Myeloid Leukemia
Scientists directly tested the role of Fas-associated phosphatase 1 in chronic myeloid leukemia-leukemia stem cells-persistence using in an in vivo murine model. [Leukemia] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
MIF Maintains the Tumorigenic Capacity of Brain Tumor-Initiating Cells by Directly Inhibiting p53
Investigators isolated primary cells from 21 human brain tumor specimens to establish cell lines with high tumorigenic potential and to identify the molecules enabling this capability. [Cancer Res] Abstract

Cervical Cancer Stem Cells Selectively Overexpress HPV Oncoprotein E6 that Controls Stemness and Self Renewal through Upregulation of HES1
Perturbation of keratinocyte differentiation by E6/E7 oncoproteins of high-risk human papillomaviruses that drive oncogenic transformation of cells in squamocolumnar junction of the uterine cervix may confer ‘stem cell like’ characteristics. Researchers examined the role of viral oncoproteins in stem cell signaling and maintenance of stemness in cervical cancer. [Clin Cancer Res] Abstract

The Role of the Aryl Hydrocarbon Receptor in the Development of Cells with the Molecular and Functional Characteristics of Cancer Stem-Like Cells
Aryl hydrocarbon receptor (AHR) activity in Hs578T triple negative and SUM149 inflammatory breast cancer cells were modulated with AHR ligands, shRNA or AHR-specific inhibitors, and phenotypic, genomic and functional stem cell-associated characteristics were evaluated. [BMC Biol] Full Article

Multiple Subsets of Brain Tumor Initiating Cells Co-Exist in Glioblastoma
Using single-cell microfluidic profiling, scientists identified multiple subpopulations of brain tumor-initiating cells co-existing in human glioblastoma, characterized by distinct surface marker expression and single-cell molecular profiles relating to distinct bulk tissue molecular subtypes. [Stem Cells] Abstract

64Cu-ATSM Therapy Targets Regions with Activated DNA Repair and Enrichment of CD133+ Cells in an HT-29 Tumor Model: Sensitization with a Nucleic Acid Antimetabolite
Using a human colon carcinoma HT-29 model, researchers demonstrated that the intratumoral 64Cu-diacetyl-bis (N4-methylthiosemicarbazone) (64Cu-ATSM) high-uptake regions exhibited malignant characteristics, such as upregulated DNA repair and elevated %CD133+ cancer stem-like cells. [Cancer Lett] Abstract

AhR Ligand Aminoflavone Inhibits α6-Integrin Expression and Breast Cancer Sphere-Initiating Capacity
Scientists investigated the ability of aryl hydrocarbon receptor (AhR) agonist Aminoflavone (AF) and AF pro-drug to disrupt mammospheres derived from breast cancer cells and a M05 mammary mouse model of breast cancer respectively. [Cancer Lett] Abstract

Fluvoxamine, an Anti-Depressant, Inhibits Human Glioblastoma Invasion by Disrupting Actin Polymerization
Researchers hypothesized that inhibitors of actin polymerization can suppress glioblastoma multiforme (GBM) migration and invasion. Fluvoxamine inhibited serum-induced ruffle formation, cell migration, and invasion of human GBM and glioma stem cells in vitro by suppressing both FAK and Akt/mammalian target of rapamycin signaling. [Sci Rep] Full Article

Let-7c Blocks Estrogen-Activated Wnt Signaling in Induction of Self-Renewal of Breast Cancer Stem Cells
By analyzing the expression levels of let-7 family members in clinical tissues, investigators found that higher expression levels of let-7b and let-7c were correlated with better clinical prognosis of patients with estrogen receptor α-positive breast tumor. [Cancer Gene Ther] Abstract

Oct4 Plays a Crucial Role in the Maintenance of Gefitinib-Resistant Lung Cancer Stem Cells
The authors previously reported that Oct4 and the putative lung cancer stem cell (CSC) marker CD133 were highly expressed in gefitinib-resistant persisters in non-small cell lung cancer (NSCLC) cells, and gefitinib-resistant persisters exhibited characteristic features of the CSCs phenotype. They elucidated the role of Oct4 in the resistance to gefitinib in NSCLC cells with an activating epidermal growth factor receptor mutation. [Biochem Biophys Res Commun] Abstract

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REVIEWS
Cancer Stem Cell Molecular Reprogramming of the Warburg Effect in Glioblastomas: A New Target Gleaned from an Old Concept
Prior targeted treatment for glioblastoma multiforme (GBM) with anti-angiogenic agents, such as bevacizumab, has been met with limited success potentially owing to GBM tumor’s ability to develop a hypoxia-induced escape mechanism – a glycolytic switch from oxidative phosphorylation to glycolysis, an old concept known as the Warburg effect. The authors examine potential enzyme targets driven by hypoxia in the glycolytic phenotype of cancer stem cells to reverse the metabolic shift induced by the Warburg effect. [CNS Oncol] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.
 
SCIENCE NEWS
Verastem Announces Oral Presentation of Data Supporting the Preferential Targeting of Ovarian Cancer Stem Cells
Verastem, Inc. announced the presentation of scientific data that provides further scientific evidence that chemotherapy can lead to an increase in ovarian cancer stem cells, making the tumor more aggressive and resistant to further treatment. [Press release from Verastem, Inc. discussing research presented at the Society of Gynecologic Oncology’s 2016 Annual Meeting on Women’s Cancer, San Diego] Press Release

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INDUSTRY NEWS
Profectus and Vyriad Form Global Collaboration to Develop Oncolytic Recombinant VSV (rVSV) Vaccines for Cancer Immunotherapy
Profectus BioSciences, Inc. and Vyriad will combine and leverage their respective rVSV-derived oncolytic and vaccine platform technologies to develop novel cancer drugs that selectively destroy tumor cells while simultaneously boosting patients’ immune systems to continue killing any residual cancer cells that may survive the initial virus attack. [Vyriad] Press Release

OncoMed Initiates Phase Ib Immuno-Oncology Combination Clinical Trial for Demcizumab and Pembrolizumab (Anti-PD1)
OncoMed Pharmaceuticals, Inc., a clinical-stage company developing novel anti-cancer stem cell and immuno-oncology therapeutics, announced dosing of the first patient in its Phase Ib clinical trial of OncoMed’s investigational agent demcizumab, with Merck’s anti-Programmed Cell Death 1 (PD1) therapy pembrolizumab. [OncoMed Pharmaceuticals, Inc.] Press Release
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Summit for Cancer Immunotherapy
June 26-29, 2016
Halifax, Canada

Visit our events page to see a complete list of events in the cancer stem cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Fellow – Division of Cancer Biology (Case Western Reserve University)

Postdoctoral Fellowship – Statistical Methods in Cancer Progression (European Molecular Biology Laboratory)

Tenure Track Position – Cancer Biology (University of Texas MD Anderson Cancer Center)

Postdoctoral Fellowship – Various Projects (University of Cincinnati)

PhD Studentship – Peptide Receptors in Cancer Stem Cells (Exiris/Bielefeld University)

Postdoctoral Fellowship – Cancer Stem Cell Biology (McGill University Health Center)

Translational Research Scientist – Hematology and Oncology (University of Chicago)

Postdoctoral Fellowship – Structures of Proteins Involved in Cancer Metastasis (European Molecular Biology Laboratory)

Full Professorship – Tumor Immunology (German Cancer Research Center)

Junior Professorship – Imaging and Radiation Oncology (German Cancer Research Center)

Postdoctoral Fellowship – Cancer Stem Cell Biology (Fred Hutchinson Cancer Research Center)

PhD Studentship – Various Positions in Cancer (Virginia Commonwealth University)

Faculty Position – Cancer Research (Various Areas) (The Jackson Laboratory)

Postdoctoral Fellowship – Cancer Epigenomics (Princess Margaret Cancer Centre)

Faculty Position – Radioimmunotherapy (Fred Hutchinson Cancer Research Center)

Research Scientist – Hematopoietic Stem Cell Transplantation (University of Chicago)

Staff Scientist – Cell Therapy Process Development (Fred Hutchinson Cancer Research Center)


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