Volume 5.09 | Mar 9

Cancer Stem Cell News 5.09 March 9, 2016
Cancer Stem Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Activation of PKA Leads to Mesenchymal-to-Epithelial Transition and Loss of Tumor-Initiating Ability
Researchers proposed a strategy to eliminate mesenchymal tumor-initiating cells by inducing their conversion to more epithelial counterparts that have lost tumor-initiating ability. [Science] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Topoisomerase IIα Mediates TCF-Dependent Epithelial–Mesenchymal Transition in Colon Cancer
T-cell factor (TCF) transcription induces epithelial–mesenchymal transition (EMT), promoting a tumor-initiating cell phenotype characterized by increased proliferation, multidrug resistance, invasion and metastasis. Researchers characterized topoisomerase IIα as a required component of TCF transcription promoting EMT. [Oncogene] Full Article

Hepatic Cancer Stem Cell Marker Granulin-Epithelin Precursor and β-Catenin Expression Associate with Recurrence in Hepatocellular Carcinoma
The authors aimed to examine granulin-epithelin precursor (GEP)-expressing cells in relation to stem cell related molecules and stem-like cell properties in a prospective hepatocellular carcinoma (HCC) clinical cohort. GEP protein levels were significantly higher in HCCs than the paralleled non-tumor liver tissues, and associated with venous infiltration. [Oncotarget] Full Article

The Matricellular Protein CCN6 (WISP3) Decreases Notch1 and Suppresses Breast Cancer Initiating Cells
Scientists discovered that ectopic CCN6 overexpression in triple negative breast cancer cells and in cells derived from patients is sufficient to induce a mesenchymal to epithelial transition and to reduce tumor initiating cells. [Oncotarget] Full Article

Rapid Recognition and Isolation of Live Colon Cancer Stem Cells by Using Metabolic Labeling of Azido Sugar and Magnetic Beads
The authors recognized cancer stem cells (CSCs) population from colon cancer cells by using metabolic labeling of azido sugar based on the quiescent nature of these cells, which differed fundamentally from previously described methods by using specific cellular markers to recognize and isolate CSCs. [Anal Chem] Abstract

Helicobacter pylori Upregulates Nanog and Oct4 via Wnt/β-Catenin Signaling Pathway to Promote Cancer Stem Cell-Like Properties in Human Gastric Cancer
Researchers found that H. pylori-infected gastric cancer cells exhibited cancer stem cell (CSC)-like properties, including an increased expression of CSC specific surface markers CD44 and Lgr5, as well as that of Nanog, Oct4 and c-myc, which are known pluripotency genes, and an increased capacity for self-renewal, whereas these properties were not observed in the CagA isogenic mutant strain-infected cells. [Cancer Lett] Full Article

Class III-Specific HDAC Inhibitor Tenovin-6 Induces Apoptosis, Suppresses Migration and Eliminates Cancer Stem Cells in Uveal Melanoma
Researchers showed that inhibition of SIRT1/2 by Tenovin-6 induced apoptosis in uveal melanoma cells by activating the expression of tumor suppressor genes such as p53 and elevating reactive oxygen species. [Sci Rep] Full Article

E-Cadherin Repression Increases Amount of Cancer Stem Cells in Human A549 Lung Adenocarcinoma and Stimulates Tumor Growth
Investigators showed that cancer stem cell amount in the human lung adenocarcinoma cell line A549 depends on E-cadherin expression. [Cell Cycle] Abstract

PI-3K Inhibitors Preferentially Target CD15+ Cancer Stem Cell Population in SHH Driven Medulloblastoma
Scientists report evidence that phosphatase and tensin homolog and phosphoinositide 3-kinase (PI-3K) play a crucial role in the propagation, survival and potential response to therapy in this CD15+ cancer stem cell/tumor propagating cell-driven malignant disease. [PLoS One] Full Article

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REVIEWS
A Glycoproteomic Approach to Identify Novel Glycomarkers for Cancer Stem Cells
Over the past several years, the authors have identified characteristic glycans on cancer stem cells (CSCs) by utilizing recent advances in glycoproteomic technologies. In this review, they summarize a series of their recent studies and discuss possible applications of glycomarkers for CSCs. [Proteomics] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.
 
INDUSTRY NEWS
Merck, Pfizer and Verastem Announce Combination Trial of Avelumab and VS-6063 in Ovarian Cancer
Merck, Pfizer and Verastem announced that they have entered into an agreement to evaluate avelumab, an investigational fully human anti-PD-L1 IgG1 monoclonal antibody, in combination with Verastem’s VS-6063, an investigational focal adhesion kinase inhibitor, in patients with advanced ovarian cancer. [Verastem] Press Release

Guided Therapeutics’ LuViva® Advanced Cervical Scan Gaining Traction in the Middle East
Guided Therapeutics, Inc. announced that the company has received an order for two LuViva® Advanced Cervical Scans, bringing to five the number of units for the Kingdom of Saudi Arabia and 10 units in the overall Middle East region. [Guided Therapeutics, Inc.] Press Release

German National Cancer Guidelines Distinguish Oncotype DX® as First and Only Multi-Gene Breast Cancer Test with 1A Level of Evidence
Genomic Health, Inc. announced the update of the German Association of Gynecological Oncology’s treatment guidelines to recognize Oncotype DX® as the only multi-gene breast cancer test with the highest 1A level of evidence. [Genomic Health, Inc.] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW ISSCR 2016 Annual Meeting
June 22-25, 2016
San Francisco, United States

Visit our events page to see a complete list of events in the cancer stem cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Fellowship – Various Projects (University of Cincinnati)

NEW PhD Studentship – Peptide Receptors in Cancer Stem Cells (Exiris/Bielefeld University)

Postdoctoral Fellowship – Cancer Stem Cell Biology (McGill University Health Center)

Translational Research Scientist – Hematology and Oncology (University of Chicago)

Postdoctoral Fellowship – Structures of Proteins Involved in Cancer Metastasis (European Molecular Biology Laboratory)

Full Professorship – Tumor Immunology (German Cancer Research Center)

Junior Professorship – Imaging and Radiation Oncology (German Cancer Research Center)

Postdoctoral Fellowship – Cancer Stem Cell Biology (Fred Hutchinson Cancer Research Center)

PhD Studentship – Various Positions in Cancer (Virginia Commonwealth University)

Faculty Position – Cancer Research (Various Areas) (The Jackson Laboratory)

Postdoctoral Fellowship – Cancer Epigenomics (Princess Margaret Cancer Centre )

Faculty Position – Radioimmunotherapy (Fred Hutchinson Cancer Research Center)

Research Scientist – Hematopoietic Stem Cell Transplantation (University of Chicago)

Staff Scientist – Cell Therapy Process Development (Fred Hutchinson Cancer Research Center)

Post-Doc Fellowship – Bioinformatics RNA Biology and Cancer (German Cancer Research Center)

Post-Doc Fellowship – Genetics and Genomics of Stem Cells (Albert Einstein College of Medicine of Yeshiva University)


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