Volume 5.03 | Jan 27

Cancer Stem Cell News 5.03 January 27, 2016
Cancer Stem Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
The Novel Tumor Suppressor Madm Regulates Stem Cell Competition in the Drosophila Testis
Researchers identified Mlf1-adaptor molecule (Madm), a novel tumor suppressor that regulates the competition between germline stem cells and somatic cyst stem cells for niche occupancy. [Nat Commun] Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
Long Non-Coding RNA DILC Represses Self-Renewal of Liver Cancer Stem Cells via Inhibiting Autocrine IL-6/STAT3 Axis
Depletion of lncRNA down-regulated in liver cancer stem cells (lnc-DILC) markedly enhanced liver cancer stem cell (LCSC) expansion and facilitated HCC initiation and progression, whereas ectopic expression of lnc-DILC dramatically inhibited LCSC expansion. Mechanistically, lnc-DILC inhibited the autocrine interleukine-6 (IL-6)/STAT3 signaling. [J Hepatol] Abstract

VEGF-A Acts via Neuropilin-1 to Enhance Epidermal Cancer Stem Cell Survival and Formation of Aggressive and Highly Vascularized Tumors
Researchers showed that epidermal cancer stem cell-produced vascular endothelial growth factor (VEGF)-A is required for the maintenance of this phenotype, as knockdown of VEGF-A gene expression or treatment with VEGF-A-inactivating antibody reduces these responses. [Oncogene] Abstract

Inhibition of FOXC2 Restores Epithelial Phenotype and Drug Sensitivity in Prostate Cancer Cells with Stem-Cell Properties
Scientists identified a critical nexus between p38MAPK signaling, and the transcription factor Forkhead Box Protein C2 (FOXC2) known to promote cancer stem-cells and metastasis. [Oncogene] Full Article

Let-7 Modulates Chromatin Configuration and Target Gene Repression through Regulation of the ARID3B Complex
Investigators demonstrated a chromatin-dependent mechanism of let-7 in regulating target gene expression in cancer cells. Let-7 directly represses the expression of AT-rich interacting domain 3B (ARID3B), ARID3A, and importin-9. [Cell Rep] Full Article | Graphical Abstract

Autotaxin Regulates Maintenance of Ovarian Cancer Stem Cells through Lysophosphatidic Acid-Mediated Autocrine Mechanism
Researchers isolated cancer stem cells (CSCs) through sphere culture of A2780, SKOV3, OVCAR3 epithelial ovarian cancer cells and primary ovarian cancer cells from patients. They identified heat-stable factors secreted from ovarian CSCs stimulated migration and proliferation of CSCs. [Stem Cells] Abstract

Plumbagin, a Naphthaquinone Derivative Induces Apoptosis and in BRCA 1/2 Defective Castrate Resistant Prostate Cancer Cells as Well as Prostate Cancer Stem-Like Cells
Scientists aimed to analyze the molecular changes elicited by plumbagin (PB) and some closely related quinones in BRCA1/2 silenced prostate cancer (PCa) cells. Specific inhibitory effect of PB on PCa Stem-Like Cell population is also revealed in this study. [Pharmacol Res] Abstract

Inhibition of Fatty Acid Synthase Decreases Expression of Stemness Markers in Glioma Stem Cells
Researchers examined the expression and role of fatty acid synthase, a key lipogenic enzyme, in glioma stem cells (GSCs). In the de novo lipid synthesis assay, GSCs exhibited higher lipogenesis than differentiated non-GSCs. [PLoS One] Full Article

Histological Characterization of the Tumorigenic “Peri-Necrotic Niche” Harboring Quiescent Stem-Like Tumor Cells in Glioblastoma
Scientists examined human astrocytoma tissues for hypoxia-inducible factor-1α-regulated quiescent stem-like tumor cells as a candidate for long-term tumorigenic cells and characterized their niche histologically. [PLoS One] Full Article

Induction of Protumoral CD11chigh Macrophages by Glioma Cancer Stem Cells through GM-CSF
Using rat C6 glioma side population cells as a model of glioma cancer stem cells (CSCs), investigators showed that CSCs induce tumor-associated macrophages development by promoting survival and differentiation of bone marrow-derived monocytes. [Genes Cells] Abstract

Endocytosis and Serpentine Filopodia Drive Blebbishield-Mediated Resurrection of Apoptotic Cancer Stem Cells
Investigators demonstrated that endocytosis drives serpentine filopodia to construct blebbishields from apoptotic bodies and that a VEGF-VEGFR2-endocytosis-p70S6K axis governs subsequent transformation. [Cell Death Discov] Full Article

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REVIEWS
Metabolic Modification in Gastrointestinal Cancer Stem Cells: Characteristics and Therapeutic Approaches
The authors analyze the potential metabolic targeting strategies for eradicating cancer stem cells that could help to develop a more effective therapeutic approach for gastrointestinal cancers. [J Cell Physiol] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.
 
INDUSTRY NEWS
ImmunoCellular Therapeutics Enters into a Sponsored Research Agreement with The University of Maryland, Baltimore to Pursue Multiple Enhancements of its Cancer Immunotherapy Platforms
ImmunoCellular Therapeutics, Ltd. announced it has entered into a sponsored research agreement with Eduardo Davila, PhD, Associate Professor of Microbiology and Immunology at the University of Maryland School of Medicine, and the University of Maryland, Baltimore. [ImmunoCellular Therapeutics, Ltd.] Press Release

BIND Therapeutics Provides Enrollment Update for Phase II iNSITE 1 and iNSITE 2 Trials with BIND-014
BIND Therapeutics, Inc. announced that the iNSITE 1 trial in non-small cell lung cancer with squamous histology is fully enrolled and data is expected to be available by the end of the first quarter of 2016. [BIND Therapeutics, Inc.] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW The Controlling Cancer Summit 2016
May 17-19, 2016
London, United Kingdom

Visit our events page to see a complete list of events in the cancer stem cell community.
 
JOB OPPORTUNITIES
NEW Post-Doc Fellowships – Integrative Analysis in Prostate and Breast Cancer (Baylor College of Medicine)

NEW Research Scientist – Hematopoietic Stem Cell Transplantation (University of Chicago)

NEW Staff Scientist – Cell Therapy Process Development (Fred Hutchinson Cancer Research Center)

Post-Doc Fellowship – Bioinformatics RNA Biology and Cancer (German Cancer Research Center)

Post-Doc Fellowship – Genetics and Genomics of Stem Cells (Albert Einstein College of Medicine of Yeshiva University)

Tenure Track Professorship – Tumor Biology and Signal Transduction (University Medical Center Gottingen)

Professor – Cancer Immunotherapy (Stanford Cancer Institute)

Postdoctoral Scientist – Follicular Lymphoma (Herbert Irving Comprehensive Cancer Center)

Postdoctoral Researcher – Prostate Cancer Biology (Roswell Park Cancer Institute)

Postdoctoral Fellow – Cell and Molecular Biology of Leukemia (Virginia Commonwealth University)

Postdoctoral Fellow – Cancer Stem Cell Biology (Cleveland Clinic)

Postdoctoral Position – Immunotherapy Targeting Cancer Stem Cells (Ecole Polytechnique Fédérale de Lausanne)


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