Volume 4.46 | Dec 9

Cancer Stem Cell News 4.46 December 9, 2015
Cancer Stem Cell News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY
Barcoding Reveals Complex Clonal Dynamics of De Novo Transformed Human Mammary Cells
Investigators present the first formal evidence of the shared and independent ability of basal cells and luminal progenitors, isolated from normal human mammary tissue and transduced with a single oncogene, to produce serially transplantable, polyclonal, invasive ductal carcinomas within eight weeks of being introduced either subrenally or subcutaneously into immunodeficient mice. [Nature] Abstract
Protocol and Data: Serum-Free, 3D Suspension Assay for Breast Cancer Cells
 
PUBLICATIONS (Ranked by impact factor of the journal)
A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes
Researchers identified an unexpected tumor suppressor function for Notch in forebrain tumor subtypes. Genetic inactivation of RBP-Jκ, a key Notch mediator, or Notch1 and Notch2 receptors accelerated PDGF-driven glioma growth in mice. [Cancer Cell] Abstract | Graphical Abstract | Press Release

Facilitated Anion Transport Induces Hyperpolarization of the Cell Membrane that Triggers Differentiation and Cell Death in Cancer Stem Cells
Scientists showed how active anionophores, capable of facilitating the transmembrane transport of chloride and bicarbonate in model phospholipid liposomes, induce acidification of the cytosol and hyperpolarization of plasma cell membranes. They demonstrated how this combined effect can be used against cancer stem cells. [J Am Chem Soc] Abstract

PTEN Deficiency Reprograms Human Neural Stem Cells towards a Glioblastoma Stem Cell-Like Phenotype
Researchers showed that targeted disruption of PTEN leads to neoplastic transformation of human neural stem cells (NSCs), but not mesenchymal stem cells. PTEN deficiency leads to the upregulation of PAX7, which in turn promotes oncogenic transformation of NSCs and instates ‘aggressiveness’ in human glioblastoma stem cells. [Nat Commun] Full Article | Press Release

HDAC Inhibition Impedes Epithelial–Mesenchymal Plasticity and Suppresses Metastatic, Castration-Resistant Prostate Cancer
To study the dynamic regulation of the epithelial–mesenchymal transition (EMT) process, researchers developed novel genetically defined cellular and in vivo model systems from which epithelial, EMT and mesenchymal-like tumor cells with Pten deletion and Kras activation can be isolated. When cultured individually, each population has the capacity to regenerate all three tumor cell populations, indicative of epithelial–mesenchymal plasticity. [Oncogene] Abstract

Identification and Analysis of CXCR4-Positive Synovial Sarcoma-Initiating Cells
Investigators analyzed whether synovial sarcoma possessed tumor-initiating cells and explored specific markers, and discovered that synovial sarcoma cell lines possessed heterogeneity by way of containing a sphere-forming subpopulation highly expressing NANOG, OCT4 and SOX2. [Oncogene] Abstract

Mesenchymal Cancer Cell-Stroma Crosstalk Promotes Niche Activation, Epithelial Reversion, and Metastatic Colonization
Scientists found that metastatic initiating cells (MICs) exhibit a high capacity for lung fibroblast activation as a result of thrombospondin 2 (THBS2) expression. Inhibiting the mesenchymal phenotype of MICs by blocking the epithelial-to-mesenchymal transition-associated kinase AXL reduces THBS2 secretion, niche-activating ability, and, consequently, metastatic competence. [Cell Rep]
Full Article | Graphical Abstract | Press Release

Genome-Wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-Like Cells
To identify therapeutic targets for glioblastoma (GBM), researchers performed genome-wide CRISPR-Cas9 knockout screens in patient-derived GBM stem-like cells and human neural stem/progenitors, non-neoplastic stem cell controls, for genes required for their in vitro growth. [Cell Rep]
Full Article | Graphical Abstract | Press Release

Niclosamide Inhibits Epithelial-Mesenchymal Transition and Tumor Growth in Lapatinib-Resistant Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer
Two human epidermal growth factor receptor 2-positive breast cancer cell lines, SKBR3 and BT474, were exposed to increasing concentrations of lapatinib to establish lapatinib-resistant cultures. [Int J Biochem Cell Biol] Abstract

View Webinar: Genome Editing: From Modeling Disease to Novel Therapeutics
 
REVIEWS
The Evolving Roles of Canonical WNT Signaling in Stem Cells and Tumorigenesis: Implications in Targeted Cancer Therapies
Scientists focus on the current understanding of WNT signaling at the extracellular, cytoplasmic membrane, and intracellular/nuclear levels, including the emerging knowledge of cross-talk with other pathways. Recent progresses in developing novel WNT pathway-targeted therapies will also be reviewed. [Lab Invest] Full Article

Glioblastoma: Defining Tumor Niches
The authors review the features and functions of the distinct glioblastoma multiforme (GBM) niches, detail the different cell constituents and the functional status of the vasculature, and discuss prospects of therapeutically targeting GBM niche constituents. [Trends Cancer] Full Article

Visit our reviews page to see a complete list of reviews in the Cancer Stem Cell research field.
 
SCIENCE NEWS
Analysis Reveals Lnc-RNA Stem Cell Signature in Acute Leukemia
Researchers at Hannover Medical School have established a core long non-coding RNA (lncRNA) stem cell signature in acute myeloid leukemia. [Press release from Hannover Medical School (Cancer Therapy Advisor) discussing research presented at the 57th American Society of Hematology (ASH) Annual Meeting, Orlando] Press Release | Abstract

Stemline Therapeutics Presents Clinical Update from Ongoing SL-401 Pivotal BPDCN Trial
Stemline Therapeutics, Inc. announced the presentation of positive clinical data, including high response rates, from the lead-in and ongoing expansion stage of its SL-401 pivotal trial in blastic plasmacytoid dendritic cell neoplasm (BPDCN). [Press release from Stemline Therapeutics, Inc. discussing research presented at the 57th American Society of Hematology (ASH) Annual Meeting, Orlando] Press Release

From our sponsor: Induce neural progenitor cells faster and more effectively. Watch the technical video.
 
INDUSTRY NEWS
ImmunoCellular Therapeutics Establishes Agreement with Alliance Foundation Trials, LLC for ICT-107 Phase III Registrational Trial in Glioblastoma
ImmunoCellular Therapeutics, Ltd. announced the establishment of an agreement with a major cancer research group, Alliance Foundation Trials, LLC, for the Phase III registrational trial of its cancer immunotherapy ICT-107 in patients with newly diagnosed glioblastoma. [ImmunoCellular Therapeutics, Ltd.] Press Release

Critical Outcome Technologies Pursues Orphan Drug Designation for COTI-2 Intended to Treat Li-Fraumeni Syndrome
Critical Outcome Technologies Inc. announced that it submitted an Orphan Drug Application intended for the treatment of Li-Fraumeni Syndrome to the U.S. Food and Drug Administration for its lead cancer drug candidate, COTI-2. [Critical Outcome Technologies Inc.] Press Release
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW The Stem Cell Niche 2016
May 22-26, 2016
Hillerod, Denmark

Visit our events page to see a complete list of events in the Cancer Stem Cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Position – Immunotherapy Targeting Cancer Stem Cells (Ecole Polytechnique Fédérale de Lausanne)

Director – Cancer Center (The University of Hawai‘i Cancer Center)

Director – Cancer Institute (North Shore-LIJ Health System)

Postdoctoral Fellow – Systems Biology of Cancer Metabolism (Technion – Israel Institute of Technology)

Postdoctoral Fellow – Epigenetics and Cancer (Moffitt Cancer Center)

Assistant Member – Radioimmunotherapy (Fred Hutchinson Cancer Research Center)

Investigator – Cancer Biology (Wake Forest Baptist School of Medicine)

Postdoctoral Research Fellow – Stem Cell Research (The University of Texas Medical School At Houston)

Faculty Positions – Cancer Pharmacology (Northwestern University)

Group Leader Position – Cancer Research (Oslo University Hospital)


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