Volume 4.41 | Oct 28

Cancer Stem Cell News 4.41 October 28, 2015
Cancer Stem Cell News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY
Ectopic Lymphoid Structures Function as Microniches for Tumor Progenitor Cells in Hepatocellular Carcinoma
Researchers studied an hepatocellular carcinoma mouse model that displayed abundant ectopic lymphoid-like structures and found that they constituted immunopathological microniches wherein malignant hepatocyte progenitor cells appeared and thrived in a complex cellular and cytokine milieu until gaining self-sufficiency. [Nat Immunol] Abstract
Learn More: Column-Free Enrichment of Mouse Mammary Stem & Progenitor Cells
 
PUBLICATIONS (Ranked by impact factor of the journal)
IRAK1 Is a Therapeutic Target that Drives Breast Cancer Metastasis and Resistance to Paclitaxel
Paclitaxel treatment induced strong interleukin-1 receptor-associated kinase 1 (IRAK1) phosphorylation, an increase in inflammatory cytokine expression, enrichment of cancer stem cells and acquired resistance to paclitaxel treatment. [Nat Commun] Full Article

Targeting Cancer Stem Cell in Castration Resistant Prostate Cancer
Scientists demonstrated immortalized normal human prostate epithelial cells, which appeared non-tumorigenic in vivo, become tumorigenic and acquired a stem cell phenotype after knocking down a tumor suppressor gene. [Clin Cancer Res] Abstract

FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-Like Breast Cancer
Scientists demonstrated that FOXC1 controls cancer stem cell (CSC) properties enriched in basal-like breast cancer cells via activation of Smoothened-independent Hedgehog (Hh) signaling. This non-canonical activation of Hh is specifically mediated by Gli2. [Cell Rep] Full Article | Graphical Abstract

Cardamonin Reduces Chemotherapy-Enriched Breast Cancer Stem-Like Cells In Vitro and In Vivo
Investigators demonstrated that cardamonin, a small molecule, selectively inhibits breast cancer stem cells (CSCs) that have been enriched by chemotherapeutic drugs. In addition, cardamonin also sufficiently prevents the enrichment of CSCs when simultaneously used with chemotherapeutic drugs. [Oncotarget] Full Article

miRNA-Regulated Delivery of lincRNA-p21 Suppresses β-Catenin Signaling and Tumorigenicity of Colorectal Cancer Stem Cells
The authors report that large intergenic non-coding RNA p21 (lincRNA-p21) is a potent suppressor of stem-like traits of cancer stem cells purified from both primary colorectal cancer tissues and cell lines. [Oncotarget] Full Article

Overshoot during Phenotypic Switching of Cancer Cell Populations
Investigators sorted human melanoma cells using three distinct cancer stem cell (CSC) markers — CXCR6, CD271 and ABCG2 — and observed that the fraction of non-CSC-marked cells first overshoots to a higher level and then returns to the level of unsorted cells. [Sci Rep] Full Article

The Role of miR-145 in Stem Cell Characteristics of Human Laryngeal Squamous Cell Carcinoma Hep-2 Cells
Researchers explored the role of miR-145, which is downregulated in laryngeal squamous cell carcinoma, on cancer stem cell potency of laryngeal cancer cells. They showed the downregulation of miR-145 expression in tumor tissue samples and in CD133-enriched cancer stem-like cells. [Tumor Biol] Abstract

Enhanced G2/M Arrest, Caspase Related Apoptosis and Reduced E-Cadherin Dependent Intercellular Adhesion by Trabectedin in Prostate Cancer Stem Cells
Investigators studied the effect of trabectedin in cell proliferation, cell cycle progression, apoptosis and spheroid formation in prostate cancer stem cells. [PLoS One] Full Article

Functional Studies of miR-130a on the Inhibitory Pathways of Apoptosis in Patients with Chronic Myeloid Leukemia
Scientists investigated the function of miR130a in p53 tumor suppressor signaling pathway. They performed microRNA expression profile analysis in chronic myeloid leukemia cancer stem cells of 38 cases and extracted total RNA from peripheral blood of 143 cases. [Cancer Gene Ther] Abstract

Free Wallchart from Nature Reviews Neuroscience on Modeling Neurological Disease with iPS Cells
 
REVIEWS
Cancer Stem Cell Targeted Therapy: Progress amid Controversies
The current status and progresses of cancer stem cells theory is illustrated and by providing a panoramic view of cancer therapy, the authors address the recent controversies regarding the feasibility of cancer stem cells targeted anti-cancer therapy. [Oncotarget] Full Article

Visit our reviews page to see a complete list of reviews in the Cancer Stem Cell research field.
 
SCIENCE NEWS
Verastem to Present Preclinical Data
Verastem, Inc. announced four poster presentations. [Press release from Verastem, Inc. discussing research to be presented at the 2015 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston] Press Release

From our sponsor: Learn about air-liquid interface culture for respiratory research. Watch the video.
 
INDUSTRY NEWS
$20 Million Commonwealth Foundation for Cancer Research Gift to Expand Collaborative Cancer Research
The Commonwealth Foundation for Cancer Research has pledged $20 million to the Bridge Project, a collaborative research program of the Koch Institute for Integrative Cancer Research at MIT and the Dana-Farber/Harvard Cancer Center, to accelerate the translation of interdisciplinary cancer solutions toward the clinic. [Massachusetts Institute of Technology] Press Release

SCRA Technology Ventures Company Kiyatec Awarded $1.725 Million to Advance Cancer STEM Cell Expansion
SCRA Technology Ventures’ SC Launch company KIYATEC announced an award of a Fast Track Phase I and Phase II Small Business Innovation Research contract for $1.725M from the National Cancer Institute. The overall goal of the contract is to develop culture systems which can grow and maintain the rare population of malignant cells referred to by some as cancer stem cells, which are believed to lead to therapy resistance, relapse and death from metastatic disease. [SCRA Technology Ventures] Press Release
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Clinical Applications of Stem Cells
February 24-25, 2016
Singapore, Singapore

Visit our events page to see a complete list of events in the Cancer Stem Cell community.
 
JOB OPPORTUNITIES
NEW Group Leader Position – Cancer Research (Oslo University Hospital)

NEW PhD Studentships – Cancer Research (Cancer Research UK Manchester Institute)

PhD Studentships – Cancer Research (University of Cambridge)

Research Associate – Pancreatic Cancer Modelling (University College London)

Postdoctoral Fellow – Leukemia Stem Cell Biology (Lund University)

Assistant, Associate or Full Professor – Hematopoietic Stem Cell Biology (Mayo Clinic)

Research Technician II – Stem Cell and Gene Therapy (Fred Hutchinson Cancer Research Center)

Postdoctoral Positions – Stem Cell, Developmental, and Cancer Biology (University of California Santa Cruz)

Postdoctoral Positions – Stem Cell, Developmental, and Cancer Biology (Columbia University Medical Center)

Assistant Professor – Stem Cell Biology (University of South Carolina)

Postdoctoral Researcher – Epigenetic Modifiers (Van Andel Research Institute)

Postdoctoral Fellow – Cancer Biology (National Cancer Institute)


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