Volume 4.39 | Oct 14

Cancer Stem Cell News 4.39 October 14, 2015
Cancer Stem Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Preferential Iron Trafficking Characterizes Glioblastoma Stem-Like Cells
Direct interrogation of iron uptake demonstrated that cancer stem-like cells (CSCs) potently extract iron from the microenvironment more effectively than other tumor cells. Systematic interrogation of iron flux determined that CSCs preferentially require transferrin receptor and ferritin, two core iron regulators, to propagate and form tumors in vivo. [Cancer Cell] Abstract | Graphical Abstract
Free Wallchart from Nature Reviews Neuroscience on Modeling Neurological Disease with iPS Cells
 
PUBLICATIONS (Ranked by impact factor of the journal)
Adult Lineage-Restricted CNS Progenitors Specify Distinct Glioblastoma Subtypes
Researchers examined the potential of adult lineage-restricted progenitors to induce fully penetrant glioblastoma multiforme using CNS progenitor-specific inducible Cre mice to mutate Nf1, Trp53, and Pten. [Cancer Cell] Abstract

Genome-Wide Screen Identified let-7c/miR-99a/miR-125b Regulating Tumor Progression and Stem-Like Properties in Cholangiocarcinoma
Researchers found that enforced expression of let-7c, microRNA (miR)-99a or miR-125b could reduce the activity of signal transducer and activator 3 and further suppress cholangiocarcinoma (CCA) tumorigenicity in vivo and inhibit the migration and invasion of CCA cells in vitro. [Oncogene] Full Article

ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy
Scientists report that ER-stress-induced activation of the unfolded protein response forces colon-cancer stem cells to differentiate, resulting in their enhanced sensitivity to chemotherapy in vitro and in vivo. [Cell Rep] Full Article | Graphical Abstract

Functional and Molecular Characterization of Cancer Stem-Like Cells in Bladder Cancer: A Potential Signature for Muscle-Invasive Tumors
The authors isolated and characterized bladder cancer stem cells making use of different functional and molecular approaches. The data obtained provide strong evidence that muscle-invasive bladder cancer is enriched with a heterogeneous stem-like population characterized by enhanced chemoresistance and tumor initiating properties, able to recapitulate the heterogeneity of the original tumor. [Oncotarget] Full Article

PI3K/AKT/mTOR and Sonic Hedgehog Pathways Cooperate Together to Inhibit Human Pancreatic Cancer Stem Cell Characteristics and Tumor Growth
Scientists examined the efficacy of combining NVP-LDE-225 and NVP-BEZ-235 on pancreatic cancer stem cells characteristics, microRNA regulatory network, and tumor growth. [Oncotarget] Full Article

Obesity Promotes Colonic Stem Cell Expansion during Cancer Initiation
Researchers assessed the effects of high fat feeding on colonic stem cell maintenance during cancer initiation and the responsiveness of stem cells to adipokine signaling pathways. [Cancer Lett] Abstract

Clinical Influence of Cancer Stem Cells on Residual Disease after Preoperative Chemoradiotherapy for Rectal Cancer
The authors evaluated the clinical influence of cancer stem cells on residual disease after preoperative chemoradiotherapy (CRT) in patients with rectal cancer. The surgical specimens of 145 patients with residual rectal cancer after preoperative CRT were assessed. [Tumor Biol] Abstract

Ideal Sphere-Forming Culture Conditions to Maintain Pluripotency in a Hepatocellular Carcinoma Cell Lines
Investigators identified and validated optimal culture conditions for sphere formation in hepatocellular carcinoma cells. Huh7 and HepG2 cells were plated in three different media types and were allowed to form spheres. [Cancer Cell Int] Full Article

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REVIEWS
Targeting Colorectal Cancer Stem Cells Using Curcumin and Curcumin Analogs: Insights into the Mechanism of the Therapeutic Efficacy
The authors highlight the efficacy of curcumin and its analogues in targeting colorectal cancer stem cell (CSC) and also the underlying molecular mechanism involved. Curcumin, in the presence or absence of other anti-cancer agents, has been shown to reduce the size of tumor mass and growth in both in vivo and in vitro studies by affecting many intracellular events that are associated with cancer progression and CSC formation. [Cancer Cell Int] Full Article

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.
 
INDUSTRY NEWS
Seattle Genetics Announces Initiation of Phase I/II Clinical Trial of ADCETRIS® (Brentuximab Vedotin) in Combination with Opdivo® (Nivolumab) in Second-Line Hodgkin Lymphoma
Seattle Genetics, Inc. announced that it has initiated a Phase I/II clinical trial of ADCETRIS in combination with Opdivo for patients with relapsed or refractory Hodgkin lymphoma after failure of frontline treatment. [Seattle Genetics, Inc.] Press Release

Cancer Research UK Launches £100 Million Grand Challenges to Tackle the Most Important Questions in Cancer
Cancer Research UK has launched Grand Challenges – the biggest and most ambitious cancer grants in the world – which aim to overcome the greatest barriers standing in the way of beating cancer. The £100 million investment will revolutionize how we diagnose, prevent and treat cancer by uniting teams of the best scientists around the world to come up with answers to crucial questions about how to save more lives from cancer. [Cancer Research UK] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Stem Cells: Development & Management
November 30-December 2, 2015
Phitsanulok, Thailand

Visit our events page to see a complete list of events in the cancer stem cell community.
 
JOB OPPORTUNITIES
NEW Research Associate – Pancreatic Cancer Modelling (University College London)

Postdoctoral Fellow – Leukemia Stem Cell Biology (Lund University)

Assistant, Associate or Full Professor – Hematopoietic Stem Cell Biology (Mayo Clinic)

Research Technician II – Stem Cell and Gene Therapy (Fred Hutchinson Cancer Research Center)

Postdoctoral Positions – Stem Cell Biology (University of California Los Angeles)

Assistant Professor – Stem Cell Biology (Stanford University)

Postdoctoral Positions – Stem Cell, Developmental, and Cancer Biology (University of California Santa Cruz)

Postdoctoral Positions – Stem Cell, Developmental, and Cancer Biology (Columbia University Medical Center)

Assistant Professor – Stem Cell Biology (University of South Carolina)

Postdoctoral Researcher – Epigenetic Modifiers (Van Andel Research Institute)

Postdoctoral Position – Immunology/Vascular Biology/Oncology (University of Toulouse)

Postdoctoral Fellow – Cancer Biology (National Cancer Institute)


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