miR-106b Induces Cell Radioresistance via the PTEN/PI3K/AKT Pathways and p21 in Colorectal Cancer
A series of in vitro and in vivo studies were performed to investigate the roles of miRNA (miR)-106b on cell radioresistance in colorectal cancer. Overexpression of miR-106b could enhance the tumor-initiating cell capacity without or with ionizing radiation condition, such as the colony sphere formation capacity and the upregulation of stemness-related genes. [J Transl Med]
Full Article
Epigallocatechin Gallate Hinders Human Hepatoma and Colon Cancer Sphere Formation
Scientists investigated the effects of epigallocatechin gallate on human hepatoma and colon cancer stem cells. Sphere-derived cells grown in serum-free, nonadherent cultures showed increased expression of stem cell markers, Nek2, and ABC transporter genes, compared with parental cells grown in conventional culture. [J Gastroenterol Hepatol] Abstract
Sensitivity of Glioma Initiating Cells to a Monoclonal Anti-EGFR Antibody Therapy under Hypoxia
Glioma initiating cells (GICs) were obtained from two patient-derived high-grade gliomas xenograft model, expressing differently EGFR. GICs were exposed to anti-EGFR monoclonal antibody cetuximab during 48 hours in 1% or 21% oxygen tension. Cell viability and self-renewal capacity were then evaluated as well as their angiogenic properties. [Life Sci] Abstract
Stem Cell-Like Gene Expression Signature Identified in Ionizing Radiation-Treated Cancer Cells
Scientists showed similar gene expression patterns between embryonic stem (ES) cells and ionizing radiation-treated cancer cells. Using genome-wide transcriptome analysis, they compared the gene expression profiles among ES cells, cancer cells, and irradiated cancer cells, and identified a subset of similar gene expression patterns between ES cells and irradiated cancer cells, indicated by hierarchical clustering. [Gene] Abstract
REVIEWS
Cancer Stem Cells and Cell Size: A Causal Link?
The authors review the evidence that primitive stem cells in adult tissues are quiescent and generally smaller than their differentiated progeny, suggesting a correlation between small cell sizes with the stemness. They also discuss cancer stem cells (CSCs) and present some evidence that correlates cell sizes with CSC activity. [Semin Cancer Biol] Abstract
Wnt Signaling in Stem Cells and Tumor Stem Cells
The author reviews the current understanding of the role of Wnt signaling in somatic stem cells and cancer stem cell/tumor-initiating cell and the potential to pharmacologically manipulate these endogenous stem cell populations (both normal and tumor). [Semin Reprod Med] Abstract
Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.
Newcastle Gets £5 Million to Boost Drug Development
Cancer Research UK’s Drug Discovery Committee has awarded Newcastle University’s Northern Institute of Cancer Research £5 million to bring more cancer drugs to clinical trials. [Cancer Research UK] Press Release
National Award for Queen’s Cancer Researchers
Cancer experts from Queen’s University Belfast have received a major award exceeding £3.6 million from Cancer Research UK aimed at developing a national digital pathology program to assist and accelerate the delivery of precision medicine in the UK. [Queen’s University Belfast] Press Release
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