Targeting Phospholipase D1 Attenuates Intestinal Tumorigenesis by Controlling β-Catenin Signaling in Cancer-Initiating Cells
Researchers showed that genetic and pharmacological targeting of phospholipase D1 (PLD1) disrupts spontaneous and colitis-associated intestinal tumorigenesis in ApcMin/+ and azoxymethane/dextran sodium sulfate mice models. PLD1 inactivation suppressed the self-renewal capacity of colon cancer-initiating cells by decreasing expression of β-catenin via E2F1-induced microRNA-4496 up-regulation. [J Exp Med] Abstract
mPGES-1 in Prostate Cancer Controls Stemness and Amplifies EGFR-Driven Oncogenicity
Researchers investigated whether expression of intrinsic microsomal PGE synthase-1 (mPGES-1) enhanced aggressiveness of prostate cancer cells and might be critical for epidermal growth factor receptor (EGFR)-mediated tumor progression. DU145 and PC-3 cell lines expressing mPGES-1 expressed stem-cell-like features as well as mesenchymal transition markers. [Endocr-Relat Cancer]
Abstract
Stem vs Non-Stem Cell Origin of Colorectal Cancer
The current paradigm is that the intestinal stem cell is the origin of colorectal cancer (CRC). However, human histology and recent studies, showing marked plasticity within the intestinal epithelium, may point to other cells of origin. The authors review these latest studies and place these in context to provide an up-to-date view of the cell of origin of CRC. [Br J Cancer]
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