CD15 Expression Does Not Identify a Phenotypically or Genetically Distinct Glioblastoma Population
Scientists demonstrated that CD15-positive (CD15+) cells were less proliferative than their CD15-negative (CD15−) counterparts in 10 patient glioblastoma (GB) tumors. They also compared the proliferative activity of CD15+ and CD15− cells in vitro using tumor-initiating primary GB cell lines and found no difference in proliferative behavior. [Stem Cells Transl Med] Abstract
Kruppel-Like Factor 4 Signals through MicroRNA-206 to Promote Tumor Initiation and Cell Survival
Scientists found that both kruppel-like factor 4 and a downstream effector, microRNA-206, are selectively enriched in the mammary cancer stem-like cells (MaCSCs) fractions of cultured human triple negative breast cancer cell lines, as well as in the aldehyde dehydrogenase-high MaCSC sub-population of cells derived from xenografted human mammary carcinomas. [Oncogenesis] Full Article
REVIEWS
The Role of Glioma Stem Cells in Chemotherapy Resistance and Glioblastoma Multiforme Recurrence
The authors discuss the molecular mechanisms of chemoresistance of glioma stem cells (GSCs) and the reasons why complete eradication of GSCs is so difficult to achieve. They also describe the targeted therapies currently available for GSCs and possible mechanisms to overcome such chemoresistance and avoid therapeutic relapse. [Expert Rev Neurother] Abstract
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