Volume 4.18 | May 13

Cancer Stem Cell News 4.18 May 13, 2015
Cancer Stem Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
miR-125b Attenuates Epithelial-Mesenchymal Transitions and Targets Stem-Like Liver Cancer Cells through SMAD2 and SMAD4
Researchers demonstrated that microRNA (miR)-125b overexpression attenuated epithelial-mesenchymal transitions (EMT) phenotype in hepatocellular carcinoma (HCC) cancer cells, while knockdown of miR-125b promoted the EMT phenotype in vitro and in vivo. They also found that miR-125b attenuated EMT-associated traits, including chemoresistance, migration and stemness in HCC cells, and negatively correlated with EMT and cancer stem cell marker expressions in HCC specimens. [Hepatology] Abstract
Learn More: Standardized Tools for Cancer Research
 
PUBLICATIONS (Ranked by impact factor of the journal)
Differential Connexin Function Enhances Self-Renewal in Glioblastoma
Scientists found that glioblastoma cancer stem cells (CSCs) possessed functional gap junctions that can be targeted using clinically relevant compounds to reduce self-renewal and tumor growth. Their analysis revealed that CSCs expressed connexin (Cx) 46, while Cx43 is predominantly expressed in non-CSCs. [Cell Rep]
Full Article
| Graphical Abstract

Chronic Chemotherapeutic Stress Promotes Evolution of Stemness and WNT/Beta-Catenin Signaling in Colorectal Cancer Cells: Implications for Clinical Use of WNT-Signaling Inhibitors
Researchers carried out a comprehensive molecular and functional analysis of six independently selected colorectal cancer cell lines with acquired resistance to three different chemotherapeutic agents derived from two distinct parental cell lines. [Oncotarget] Full Article

The Critical Roles of Tumor-Initiating Cells and the Lymph Node Stromal Microenvironment in Human Colorectal Cancer Extranodal Metastasis Using a Unique Humanized Orthotopic Mouse Model
The authors investigated the interactions between CD133+CXCR4+ colorectal cancer tumor-initiating cells and the lymph node stromal microenvironment in human colorectal cancer extranodal metastasis. [FASEB J] Abstract

Identification of Thioridazine, an Antipsychotic Drug, as an Antiglioblastoma and Anticancer Stem Cell Agent Using Public Gene Expression Data
Investigators hypothesized that if treatment with a drug could reverse, at least in part, the gene expression signature of glioblastoma (GBM) and GBM stem cells, this drug may have the potential to inhibit pathways essential in the formation of GBM and thereby treat GBM. Therefore, they systematically evaluated the in vitro antitumor effects of 79 drugs in GBM cell lines. [Cell Death Dis] Full Article

Let-7a Regulates Mammosphere Formation Capacity through Ras/NF-κB and Ras/MAPK/ERK Pathway in Breast Cancer Stem Cells
Researchers illustrated that overexpression of let-7a reduced cell proliferation and mammosphere formation ability of breast cancer stem cells in a KRas-dependent manner through different pathways in vitro and in vivo. They provided the evidence that let-7a was decreased, and reversely the expression of KRas was increased with moderate expression in early stages and high expression in advanced stages in breast cancer specimens. [Cell Cycle] Abstract

Molecular Heterogeneity in a Patient-Derived Glioblastoma Xenoline Is Regulated by Different Cancer Stem Cell Populations
Scientists characterized glioblastoma tumors produced by subcutaneous and intracranial injection of adherent cultures of glioblastoma stem-like cell (GSC) and spheroid cultures of GSCs (Sp-GSCs) isolated from a patient-derived xenoline. Although they formed tumors with identical histological features, gene expression analysis revealed that xenografts of Sp-GSCs had a classical molecular subtype similar to that of bulk tumor cells. [PLoS One] Full Article

ATOH1 Can Regulate the Tumorigenicity of Gastric Cancer Cells by Inducing the Differentiation of Cancer Stem Cells
Researchers showed that ATOH1 can induce the differentiation of gastric cancer stem cells (GCSCs). The lentivirus-induced overexpression of ATOH1 in GCSCs and in gastric cancer cell lines significantly induced differentiation, reduced proliferation and sphere formation, and reduced in vivo tumor formation in the subcutaneous injection and liver metastasis xenograft models. [PLoS One] Full Article

GnRH Participates in the Self-Renewal of A549-Derived Lung Cancer Stem-Like Cells through Upregulation of the JNK Signaling Pathway
Investigators isolated and identified a subpopulation of lung cancer stem-like cells from non-small cell lung carcinoma A549 cells with features including self-renewal capacity in vitro, elevated tumorigenic activity in vivo, and high expression of stemness markers CD44, CD133, aldehyde dehydrogenase and Sox2, using a serum-free suspension sphere-forming culture method. [Oncol Rep] Abstract

Protocol and Data: Serum-Free, 3D Suspension Assay for Breast Cancer Cells
 
REVIEWS
Cancer Stem Cells and Tumor-Associated Macrophages: A Roadmap for Multitargeting Strategies
The authors summarize the recent molecular data concerning the multilayered relationship between cancer stem cells and tumor-associated macrophages that form a key component of the tumor microenvironment. They also discuss the therapeutic implications of targeting this synergistic interplay. [Oncogene] Abstract

Alternative Treatments For Melanoma: Targeting BCL-2 Family Members to De-Bulk and Kill Cancer Stem Cells
The authors discuss the recent advancements in targeting BCL-2 family members for cancer treatments, and how this approach can be applied as an alternative option to combat melanoma, and overcome melanoma relapse or resistance in current treatment regimens. [J Invest Dermatol] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

Target Cancer Metabolism
 
INDUSTRY NEWS
Propanc to Study Effects of PRP on Cancer Stem Cells
Propanc Health Group Corporation announced that the company will be investigating the effects of PRP against cancer stems cells with its joint research partner at the University of Jaen, Spain. [Propanc Health Group Corporation] Press Release

Redx Reaches Pre-Clinical Proof of Concept with Oncology Lead
Redx Pharma has reached pre-clinical proof of concept stage with an advanced lead which has the potential to tackle some of the most hard-to-treat cancers. The novel, potent small molecule Porcupine inhibitor targets the Wnt pathway, an embryonic signaling pathway that is implicated in the maintenance of cancer stem cells in multiple cancer types. [Redx Pharma Plc] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW ICCSCE 2016 : 18th International Conference on Cell and Stem Cell Engineering
September 15-16, 2016
Rome, Italy

Visit our events page to see a complete list of events in the cancer stem cell community.
 
JOB OPPORTUNITIES
NEW PhD Student – Cancer Stem Cell Immunology (Cardiff University)

PhD Position – Neurology & Cancer Stem Cells (Cardiff University)

Postdoctoral Positions – Epigenetics, Stem Cells and Cancer (University of Copenhagen)

Postdoctoral Positions – Cancer Stem Cell Biology (Weill Cornell College of Medicine)

Postdoctoral Position – Cancer Research (INSERM)

Postdoctoral Fellow – Colon Cancer (Baylor Research Institute)

Postdoctoral Research Fellow – Cell Death of Normal Tissue Stem Cells & Cancer Stem Cells (Memorial Sloan Kettering Cancer Center)

Postdoctoral Position – Cancer Biology (University of Pennsylvania)

Postdoctoral Fellow – Breast Cancer & Stem Cell Biology (University of Cincinnati)


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