Volume 4.01 | Jan 14

Newsletter Issue
Cancer Stem Cell News 4.01 January 14, 2015
Cancer Stem Cell News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY
New Mechanism Involved in Skin Cancer Tumor Initiation, Growth and Progression
Researchers report the mechanisms regulating the different functions of Twist1 controlling skin tumor initiation, cancer stem cell function and tumor progression. They used state of the art genetic mouse models to dissect the functional role and molecular mechanisms by which Twist1 controls tumor initiation, cancer stem cell function and tumor progression. [Press release from the Free University of Brussels (Medical Xpress) discussing online prepublication in Cell Stem Cell] Press Release | Abstract | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Periostin Secreted by Glioblastoma Stem Cells Recruits M2 Tumor-Associated Macrophages and Promotes Malignant Growth
Investigators interrogated the molecular link between glioma stem cells (GSCs) and tumor-associated macrophage (TAMs) recruitment in glioblastoma multiformes and demonstrated that GSCs secrete ​periostin to recruit TAMs. [Nat Cell Biol] Full Article

Knockdown of Long Non-Coding RNA XIST Exerts Tumor-Suppressive Functions in Human Glioblastoma Stem Cells by Up-Regulating miR-152
Scientists elucidated the function and the possible molecular mechanisms of lncRNA XIST in human glioblastoma stem cells. Functionally, knockdown of XIST exerted tumor-suppressive functions by reducing cell proliferation, migration and invasion as well as inducing apoptosis. [Cancer Lett] Abstract

Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion
Inhibition of autophagy by knockdown of ATG7 or BECN1 modified the CD44+/CD24low/- population in breast cancer cells by regulating CD24 and IL6 secretion. Researchers reveal that autophagy regulates breast cancer stem cell maintenance in autophagy-dependent breast cancer cells by modulating IL6 secretion implicating autophagy as a potential therapeutic target in breast cancer. [Mol Cancer Res] Abstract

SOD2 Is a C-Myc Target Gene That Promotes the Migration and Invasion of Tongue Squamous Cell Carcinoma Involving Cancer Stem-Like Cells
Scientists clarified the mechanisms of manganese superoxide dismutase (SOD2) in the migration and invasion of tongue squamous cell carcinoma. Side population cells were used as cancer stem-like cells and assessed by sphere and colony formation assays, and the expression of stem cell markers. [Int J Biochem Cell Biol] Abstract | Graphical Abstract

Acetate Supplementation as a Means of Inducing Glioblastoma Stem-Like Cell Growth Arrest
The authors characterized the effects of glyceryl triacetate on the proliferation and differentiation of six primary glioblastoma (GBM)-derived glioma stem-like cells relative to established U87 and U251 GBM cell lines, normal human cerebral cortical astrocytes, and murine neural stem cells. [J Cell Physiol] Abstract

1H NMR Spectroscopy of Glioblastoma Stem-Like Cells Identifies Alpha-Aminoadipate as a Marker of Tumor Aggressiveness
Metabolite profiles of 42 glioblastoma multiforme (GBM) cells with stem-like properties lines established from the tumor tissue of adult GBM patients were screened with 1H NMR spectroscopy and compared with human neural progenitor cells from human adult olfactory bulb and from the developing human brain. [NMR Biomed] Abstract

Inhibitory Action of Pristimerin on Hypoxia-Mediated Metastasis Involves Stem Cell Characteristics and EMT in PC-3 Prostate Cancer Cells
The authors investigated whether pristimerin affects the bone metastasis, stem cell characteristics and epithelial-mesenchymal transition (EMT) of prostate cancer PC-3 cells subjected to hypoxia. [Oncol Rep] Abstract

A Flexible Reporter System for Direct Observation and Isolation of Cancer Stem Cells
Investigators developed a flexible lentiviral-based reporter system that allows direct visualization of cancer stem cells based on functional properties. [Stem Cell Rep] Full Article | Graphical Abstract

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REVIEWS
Cervical Cancer Stem Cells: Opportunities and Challenges
The author highlights the current status of research on cervical cancer stem cells, their clinical significance and the challenges in the field. [J Cancer Res Clin Oncol] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.
 
SCIENCE NEWS
Regen BioPharma Inc. Identifies Second Generation Gene Silencing Candidates for Blocking Cancer Stem Cell Gene Target
Regen BioPharma Inc. announced the discovery and demonstration of in vitro efficacy of a second generation of gene silencing drug candidates with specificity to the cancer stem cell gene NR2F6. [Regen BioPharma Inc. (Marketwired, Inc.)] Press Release

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INDUSTRY NEWS
Canadian Cancer Clinical Trials Network Receives New Funding, Launches Online Service to Connect Patients to Clinical Trials
Canadian Cancer Clinical Trials Network (3CTN) announced that it has received funding support from the Ontario Institute for Cancer Research, the Canadian Partnership Against Cancer, the Canadian Breast Cancer Foundation, and CancerCare Manitoba. The funding will be used to establish the network’s sites at cancer centers conducting clinical trials across Canada. [3CTN (PR Newswire Association LLC)] Press Release

Prostate Cancer Foundation Announces 6 New Challenge Awards for New Discoveries in Treatment Sciences
The Prostate Cancer Foundation (PCF) announced six new Challenge Awards to advance the treatment of lethal prostate cancer. PCF Challenge Awards are multi-year awards supporting cross-disciplinary teams of research scientists. $39 million went toward supporting research programs in 2014. [Prostate Cancer Foundation]
Press Release
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW CIRM 2.0 Free Webinar – Changing the Way We Work
January 21, 2015 12:00 PM PST
Online

NEW Clinical Applications of Stem Cells
February 26-27, 2015
Singapore, Singapore

NEW 4th International Conference on Immunochemotherapy
April 16-17, 2015
Philadelphia, United States

Visit our events page to see a complete list of events in the cancer stem cell community.
 
JOB OPPORTUNITIES
NEW Junior Group Leaders – Cell Biology of Cancer and Genomic Instability (Foundation FIRC Institute of Molecular Oncology)

NEW Postdoctoral Position – Stem Cell Biology/Cancer Biology (Oregon Health & Science University)

NEW Postdoctoral Positions – Cancer Bioengineering and Cancer Biology (University of Minnesota)

Postdoctoral Fellow – Wnt Signaling in Development and Disease (Van Andel Research Institute)

Postdoctoral Research Fellow – Post-Transcriptional Gene Regulation Governing Cancer Cell Behavior (Fred Hutchinson Cancer Research Center)

Postdoctoral Positions – Functional Genomics of Stem Cells and Cancer (UT Southwestern Medical Center)

Postdoctoral Fellow – Cancer Stem Cell Biology (University of Edinburgh)

Postdoctoral Fellow – Cancer Stem Cell Biology (Genome Institute of Singapore)

Postdoctoral Position – Cancer and Developmental Biology (University of California, Irvine)

Postdoctoral Fellow – Stem Cells and Cancer (Tsinghua University)

Postdoctoral Position – Pluripotent Stem Cell Biology and Cancer Research (Memorial Sloan-Kettering Cancer Center)

Principal Investigator – Cancer Biochemist (Wake Forest Baptist Medical Center)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)


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