KAP1 Promotes Proliferation and Metastatic Progression of Breast Cancer Cells
Scientists report that the expression of many KRAB family zinc finger proteins along with active SUMOlyated KAP1 is elevated widely in human breast cancers. KAP1 silencing in breast cancer cells reduced proliferation and inhibited the growth and metastasis of tumor xenografts. [Cancer Res] Abstract
Overexpression of miR-200a Suppresses Epithelial-Mesenchymal Transition of Liver Cancer Stem Cells
Researchers investigated the role of miR-200a in regulation of epithelial-mesenchymal transition phenotype of liver cancer stem cells (LCSCs). They used side population (SP) sorting to obtain cancer stem-like cells from hepatocellular carcinoma cell lines and identified that the SP fraction could be enriched with LCSCs. [Tumour Biol] Abstract
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