Targeting the c-Met/FZD8 Signaling Axis Eliminates Patient-Derived Cancer Stem-Like Cells in Head and Neck Squamous Carcinomas
Scientists report that silencing c-Met is sufficient to suppress sphere formation, tumor initiation and metastatic properties of head and neck-cancer stem-like cells (CSC). Pharmacologic inhibition of c-Met with the selective inhibitor PF-2341066 preferentially targeted CSC and synergized with conventional chemotherapy to improve efficacy in a mouse xenograft model of head and neck squamous carcinomas, impeding tumor growth and reducing metastasis. [Cancer Res] Abstract|Full Article
SOX2 Regulates Self-Renewal and Tumorigenicity of Stem-Like Cells of Head and Neck Squamous Cell Carcinoma
Researchers created cells ectopically expressing sex-determining region Y-box (SOX2) from previously established head and neck squamous cell carcinomas (HNSCC) cells and examined the cell proliferation, self-renewal capacity, and chemoresistance of these cells compared with control cells. In addition, they knocked down SOX2 in primary spheres obtained from HNSCC tumor tissue and assessed the attenuation of stemness-associated traits in these cells in vitro and in vivo. [Br J Cancer] Abstract
New Strategies in Acute Myelogenous Leukemia: Leukemogenesis and Personalized Medicine
The authors review select novel approaches to therapy of acute myelogenous leukemia such as targeting leukemia stem cells, altering leukemia/marrow microenvironment interactions, inhibiting DNA repair or cell cycle checkpoints, and augmenting immune-based anti-leukemia activity. [Clin Cancer Res] Abstract
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