Volume 3.31 | Aug 13

Cancer Stem Cell News 3.31 August 13, 2014
Cancer Stem Cell News
     In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY
Researchers Discover a Metabolic Mechanism for Resistant Pancreatic Cancer
Knock out a genetic mutation that’s a driving force behind pancreatic cancer and a few cells quietly hunker down in the resulting scar tissue, nibbling on themselves to survive before roaring back as resistant disease that taps the cell’s normal powerhouses to thrive. Scientists revealed this mode of metabolic resistance to targeted cancer therapy and a way to attack it. [Press release from The University of Texas MD Anderson Cancer Center discussing online prepublication in Nature] Press Release | Abstract
Protocol and Data: Serum-Free, 3D Suspension Assay for Breast Cancer Cells
 
PUBLICATIONS (Ranked by impact factor of the journal)
Arachidonate 15-Lipoxygenase Is Required for Chronic Myeloid Leukemia Stem Cell Survival
Scientists determined that the gene encoding arachidonate 15-lipoxygenase is essential for the survival of leukemia stem cells in a murine model of BCR-ABL-induced chronic myeloid leukemia. [J Clin Invest]
Full Article

Phenformin-Loaded Polymeric Micelles for Targeting Both Cancer Cells and Cancer Stem Cells In Vitro and In Vivo
Researchers show that the drug-loaded micelles were more effective in inhibiting the growth of both side population (SP) and non-SP cells. In vivo studies conducted in an H460 human lung cancer mouse model demonstrated that the drug-loaded micelles had greater anti-tumor efficacy, and reduced the population of SP cells in the tumor tissues more effectively than free phenformin. [Biomaterials] Abstract

Proliferation and Enrichment of CD133+ Glioblastoma Cancer Stem Cells on 3D Chitosan-Alginate Scaffolds
Scientists report that growing cells from glioblastoma cell lines on three dimensional (3D) porous chitosan-alginate scaffolds dramatically promotes the proliferation and enrichment of cells possessing the hallmarks of cancer stem cells. [Biomaterials] Abstract

SIRT1 Is Required for Oncogenic Transformation of Neural Stem Cells and for the Survival of “Cancer Cells with Neural Stemness” in a p53-Dependent Manner
Researchers demonstrate that the expression of silent mating type information regulation 2, homolog (SIRT1), expressed in “cancer cells with neural stemness,” is critical not only for the maintenance of stem cells, but also for oncogenic transformation. [Neuro Oncol] Abstract

MicroRNA-1246 Expression Associated with CCNG2-Mediated Chemoresistance and Stemness in Pancreatic Cancer
The in vitro drug sensitivity of pancreatic cancer cells was altered according to microRNA (miR)-1246 expression via CCNG2. In vivo, scientists found that miR-1246 could increase tumor-initiating potential and induced drug resistance. [Br J Cancer] Abstract

Vaccination with ErbB-2 Peptides Prevents Cancer Stem Cell Expansion and Suppresses the Development of Spontaneous Tumors in MMTV-PyMT Transgenic Mice
Researchers investigated a peptide-based vaccine, which consists of two MHC class II epitopes derived from murine ErbB-2, to prevent the occurrence of spontaneous tumors in breast and assess immune impact on breast cancer stem cells. [Breast Cancer Res Treat] Abstract

Down-Regulation of Sp1 Suppresses Cell Proliferation, Clonogenicity and the Expressions of Stem Cell Markers in Nasopharyngeal Carcinoma
Researchers investigated the cellular function of Sp1 and aimed to verify the clinical significance of Sp1 as a potential therapeutic target in nasopharyngeal carcinoma. [J Transl Med] Full Article

Potential Effect of Matrix Stiffness on the Enrichment of Tumor Initiating Cells under Three-Dimensional Culture Conditions
The potential effect of matrix stiffness on the biological characteristics of human head and neck squamous cell carcinoma (HNSCC) tumor initiating cells (TICs), especially the enrichment of HNSCC TICs, was investigated under three-dimensional culture conditions by means of alginate gel beads with different matrix stiffnesses. [Exp Cell Res] Abstract

The Ordered Acquisition of Class II and Class I Mutations Directs Formation of Human t(8;21) Acute Myelogenous Leukemia Stem Cell
Scientists show that in t(8;21) acute myelogenous leukemia, hematopoietic stem cells transform into leukemia stem cells via definitively-ordered acquisition of Class II and then Class I abnormalities. [Exp Hematol] Abstract

Cancer Stem-Like Cells from Head and Neck Cancers Are Chemosensitized by the Wnt Antagonist, sFRP4, by Inducing Apoptosis, Decreasing Stemness, Drug Resistance and Epithelial to Mesenchymal Transition
Researchers found that an antagonist of FrzB/Wnt, the secreted frizzled-related protein 4 (sFRP4), inhibited the growth of cancer stem cells from two head and neck squamous cell carcinoma cell lines, Hep2 and KB. [Cancer Gene Ther] Abstract

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REVIEWS
Cancer Stem Cells: Perspectives for Therapeutic Targeting
Although cancer stem cells (CSCs) still need to be fully characterized, potential candidate markers and/or signaling pathways to be exploited for the design of novel CSC-targeting therapeutic strategies are described in this review. [Cancer Immunol Immunother] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.
 
SCIENCE NEWS
Epizyme Presents Pre-Clinical Data and Early Clinical Observations from Ongoing Phase I Trial of EZH2 Inhibitor EPZ-6438 (E7438)
Epizyme, Inc. reported pre-clinical data and early clinical observations from an ongoing Phase I trial, being conducted in collaboration with Eisai, the Institut Gustave Roussy, and the Institut Bergonie, of EZH2 inhibitor EPZ-6438 (E7438) in patients with advanced solid tumors and B-cell lymphomas. [Press release from Epizyme, Inc. discussing research presented at the American Society of Hematology (ASH) Meeting on Lymphoma Biology, Colorado Springs] Press Release

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INDUSTRY NEWS
Avillion Announces Dosing of First Patients in Phase III BFORE Trial to Assess BOSULIF® (Bosutinib) as First-Line Treatment for Patients with Chronic Myelogenous Leukemia
Avillion LLP announced that the first patients have been dosed in the United States in a global Phase III clinical trial called “BFORE,” which is designed to assess the effectiveness and safety of BOSULIF® (bosutinib) as a first-line treatment for patients with chronic phase Philadelphia chromosome positive chronic myelogenous leukemia. [Avillion LLP] Press Release

Seattle Genetics Initiates Phase I Clinical Trial of Antibody-Drug Conjugate SGN-CD70A for Non-Hodgkin Lymphoma and Renal Cell Carcinoma
Seattle Genetics, Inc. announced the initiation of a Phase I clinical trial evaluating SGN-CD70A for CD70-positive relapsed or refractory non-Hodgkin lymphoma and metastatic renal cell carcinoma. [Seattle Genetics, Inc.] Press Release

FDA Grants Orphan Drug Designation for OncoSynergy’s Investigational Monoclonal Antibody OS2966 in the Treatment of Glioblastoma
OncoSynergy announced that the FDA Office of Orphan Products Development has granted orphan drug designation for the investigational drug candidate OS2966, a neutralizing anti-CD29 monoclonal antibody, for the treatment of glioblastoma, the most common and deadliest primary adult brain tumor. [OncoSynergy (PR Newswire Association LLC)] Press Release
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration Australia)
 
EVENTS
NEW 13th Annual AACR International Conference on Frontiers in Cancer Prevention Research
September 28-October 1, 2014
New Orleans, United States

NEW Stem Cell Meeting on the Mesa
October 7-9, 2014
La Jolla, United States

Visit our events page to see a complete list of events in the cancer stem cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Research Fellow – Induced Pluripotent Stem Cell Based Therapeutics (Fred Hutchinson Cancer Research Center)

Tenure Track Positions – Cancer Biology (Wake Forest Baptist Medical Center)

PhD Student – Cancer Stem Cells (KU Leuven)

Technical Account Manager (GlobalStem)

Postdoctoral Position – Molecular Properties of Leukemic Stem Cells (BC Cancer Agency)

Postdoctoral Research Associate – Cancer Stem Cell Biology (University of California, San Diego)

Postdoctoral Position – Stem Cells and Cancer (Brigham & Women’s Hospital – Harvard Medical School)

Research Assistant/Research Associate – Stem Cell and Cancer Biology (University of North Texas Health Science Center)

Postdoctoral Fellowships – Cancer Research (German Cancer Research Center [DKFZ])

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)


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