Volume 3.27 | Jul 16

Cancer Stem Cell News 3.27 July 16, 2014
Cancer Stem Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
Cell Therapy News on Facebook  Cancer Stem Cell News on Twitter
 
TOP STORY
Acute Myelogenous Leukemia-Induced Sympathetic Neuropathy Promotes Malignancy in an Altered Hematopoietic Stem Cell Niche
The interactions and influence of acute myelogenous leukemia (AML) stem cells with the microenvironment remain largely unexplored. Scientists found that neuropathy of the sympathetic nervous system promotes leukemic bone marrow infiltration in an MLL-AF9 AML model. [Cell Stem Cell] Full Article | Graphical Abstract
Request Sample: ReLeSR™, Easy Passaging Through Selective Detachment of hPSCs
 
PUBLICATIONS (Ranked by impact factor of the journal)
Radiotherapy-Induced Plasticity of Prostate Cancer Mobilizes Stem-Like Non-Adherent, Erk Signaling-Dependent Cells
Exposure of four metastasis-derived human prostate cancer cell lines to clinically relevant daily fractions of ionizing radiation resulted in generation of two radiation-surviving populations: adherent senescent-like cells expressing common senescence-associated markers and non-adherent anoikis-resistant stem cell-like cells with active Notch signaling and expression of stem cell markers CD133, Oct-4, Sox2 and Nanog. [Cell Death Differ] Abstract

Surgery-Induced Wound Response Promotes Stem-Like and Tumor-Initiating Features of Breast Cancer Cells, via STAT3 Signaling
Scientists discovered that wound fluids (WF) induced the enrichment of breast cancer cells with stem-like phenotypes, via activation of STAT3. In vitro, WF highly stimulated mammosphere formation and self-renewal of breast cancer cells. In vivo, STAT3 signaling was critical for breast cancer cell tumorigenicity and for the formation of local relapse after surgery. [Oncotarget] Abstract

Autophagy Inhibition Suppresses the Tumorigenic Potential of Cancer Stem Cell Enriched Side Population in Bladder Cancer
Scientists isolated the side population (SP) cells which share characteristics of cancer stem cells from bladder cancer cell lines, T24 and UM-UC-3 by fluorescence activated cell sorting. The cells were cultured in serum free medium and expression profile of stem cell like markers and drug resistant genes and spheroid forming capability were examined in SP, non-side population and bulk T24 and UM-UC-3 cells. [Biochim Biophys Acta] Abstract

Fe-bLf Nanoformulation Targets Survivin to Kill Colon Cancer Stem Cells and Maintains Absorption of Iron, Calcium and Zinc
Researchers aimed to validate the anticancer efficacy of alginate-enclosed, chitosan-conjugated, calcium phosphate, iron-saturated bovine lactoferrin (Fe-bLf) nanocarriers/nanocapsules with improved sustained release and ability to induce apoptosis by downregulating survivin, as well as cancer stem cells. [Nanomedicine] Abstract | Full Article

Meis1 Regulates Epidermal Stem Cells and Is Required for Skin Tumorigenesis
Scientists uncovered two roles for Meis1 in the epidermis: as a critical regulator of epidermal homeostasis in normal tissues and as a proto-oncogenic factor in neoplastic tissues. [PLoS One] Full Article

Both Canonical and Non-Canonical Wnt Signaling Independently Promote Stem Cell Growth in Mammospheres
Ex vivo mammosphere cultures were established from both wild-type and Wnt1 transgenic mice and were analyzed in response to manipulation of both canonical and non-canonical Wnt signaling. An increased level of mammosphere formation was observed in cultures derived from MMTV-Wnt1 versus wild-type animals, and this was blocked by treatment with Dkk1, a selective inhibitor of canonical Wnt signaling. [PLoS One] Full Article

Sphere-Forming-Like Cells (Squamospheres) with Cancer Stem-Like Cell Traits from VX2 Rabbit Buccal Squamous Cell Carcinoma
Researchers studied the spheroid cells from VX2 rabbit buccal squamous cell carcinomas and assess their cancer stem cell characteristics. [Int J Oral Sci] Full Article

β-Carotene Inhibits Neuroblastoma Tumorigenesis by Regulating Cell Differentiation and Cancer Cell Stemness
The effects of β-Carotene (BC) on tumor cell differentiation and tumorigenicity was investigated using a xenograft model. BC treatment has been shown to significantly suppress tumor stemness by down-regulating cancer stem cell markers such as Oct 3/4 and DLK1. [Biochem Biophys Res Commun] Abstract

Neuregulin-1 Induces Cancer Stem Cell Characteristics in Breast Cancer Cell Lines
Researchers showed that neuregulin-1 (NRG1) treatment induced cancer stem cell (CSC) characteristics in breast cancer cell lines. Using breast cancer cell lines, MCF-7, SKBr-3 and MDA-MB 468, changes related to CSC characteristics were analyzed. Flow cytometry was used to analyze changes in CSC fractions in multiple cell lines after NRG1 treatment. [Oncol Rep] Abstract

Knockdown of Nuclear Factor Erythroid 2-Related Factor 2 by Lentivirus Induces Differentiation of Glioma Stem-Like Cells
Scientists knocked down nuclear factor erythroid 2-related factor 2 (Nrf2) from glioma stem cells (GSCs) to investigate the role of Nrf2 in the differentiation of GSCs. First, Nrf2 expression was observed at different stages of differentiation; then, Nrf2 was knocked down and the association of Nrf2 with differentiation degree was observed in vitro. [Oncol Rep] Abstract

Targeting Cancer Stem Cell Plasticity through Modulation of Epidermal Growth Factor and Insulin-Like Growth Factor Receptor Signaling in Head and Neck Squamous Cell Cancer
Researchers aimed to establish an in vitro system that recapitulates stem cell plasticity in head and neck squamous cell cancers and identify the factors that play a role in the maintenance and repopulation of cancer stem cells. [Stem Cells Transl Med] Abstract

MammoCult™: Most Published Mammosphere & Tumorsphere Culture Medium (Commercially Available) FREE Sample Request
 
REVIEWS
Cancer Stem Cells, Cancer Cell Plasticity and Radiation Therapy
The authors discuss recent reports challenging the idea of a unidirectional differentiation of cancer cells. These reports provide evidence supporting the idea that non-stem cancer cells exhibit a remarkable degree of plasticity that allows them to re-acquire cancer stem cell traits, especially in the context of radiation therapy. [Semin Cancer Biol] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.
 
INDUSTRY NEWS
No Stomach for Cancer Awards $100,000 in New Research Grants in Gastric Cancer
No Stomach For Cancer announced two $50,000 grant awards to fund exploration of the development of gastric cancer. In keeping with the organization’s mission, these grants will facilitate research projects that hold the promise of improving prevention, diagnosis and treatment of this disease. [No Stomach For Cancer, Inc.]
Press Release

Lilly and Immunocore Enter Immunotherapy Agreement to Co-Discover and Co-Develop Novel Cancer Therapies
Eli Lilly and Company and Immunocore Limited announced they have entered into a co-discovery and co-development collaboration to research and potentially develop novel T cell-based cancer therapies. [Eli Lilly and Company] Press Release

Bristol-Myers Squibb Announces Plans for Third Quarter Submission of a Biologics License Application for Opdivo® (Nivolumab), an Investigational PD-1 Immune Checkpoint Inhibitor, for Previously Treated Advanced Melanoma
Bristol-Myers Squibb Company announced that, following discussions with the U.S. Food and Drug Administration, the company is planning a third quarter submission of a biologics licensing application for Opdivo® (nivolumab) for previously treated advanced melanoma. [Bristol-Myers Squibb Company] Press Release

From our sponsor:
Interested in assays for human mammary stem and progenitor cells?
Request your free wallchart.
 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Advances in Stem Cell Research (ASCR) 2014
September 16-17, 2014
Online

Visit our events page to see a complete list of events in the cancer stem cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Position – Molecular Properties of Leukemic Stem Cells (BC Cancer Agency)

NEW Product Marketing Manager (Cesca Therapeutics)

Postdoctoral Fellow – Genome Editing in Human Embryonic Stem Cells to Study Hereditary Cancer-Associated Mutations (UConn Health Center)

PhD Candidate – Mammary Stem Cell Biology (University of Amsterdam)

Postdoctoral Research Associate – Cancer Stem Cell Biology (University of California, San Diego)

Postdoctoral Position – Stem Cells and Cancer (Brigham & Women’s Hospital – Harvard Medical School)

Research Assistant/Research Associate – Stem Cell and Cancer Biology (University of North Texas Health Science Center)

Postdoctoral Fellow – Stem Cells and Cancer (Albert Einstein College of Medicine in New York)

Postdoctoral Fellow – Cancer and Stem Cell Biology (University of Pennsylvania)

PhD Scholarship – Inorganic Nanoparticles for Cancer Stem Cell Targeting and Detection (The Italian Institute of Technology)

Postdoctoral Fellowships – Cancer Research (German Cancer Research Center [DKFZ])

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)


Recruit Top Talent: Reach more than 50,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
 

Have we missed an important article or publication in Cancer Stem Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here
Learn more about Cancer Stem Cell News: Archives | Events | Contact Us