Wnt Inhibitory Factor 1 Suppresses Cancer Stemness and Induces Cellular Senescence
Scientists report for the first time that downregulation of the Wnt inhibitory factor 1 (WIF1) is a widespread event in salivary gland carcinoma ex-pleomorphic adenoma (CaExPA). They also showed that WIF1 downregulation occurs in the CaExPA precursor lesion pleomorphic adenoma and indicates a higher risk of progression from benign to malignant tumor. [Cell Death Dis]
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Role of Fbxw7 in the Maintenance of Normal Stem Cells and Cancer-Initiating Cells
The authors summarize current understanding of the role of F-box and WD40 repeat domain-containing 7 (Fbxw7), a key regulator of the cell cycle, in the maintenance of normal stem cells and cancer-initiating cells, as well as attempts to define future challenges in this field. [Br J Cancer]
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Brain Metastasis-Initiating Cells: Survival of the Fittest
Despite the high rate of brain metastases (BMs)-associated mortality, very little research is conducted in this area. Lack of research and staggeringly low patient survival is indicative that a novel approach to BMs and their treatment is needed. [Int J Mol Sci]
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