Volume 3.07 | Feb 26

Cancer Stem Cell News 3.07 February 26, 2014
Cancer Stem Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Identification of Small Molecules that Support Human Leukemia Stem Cell Activity Ex Vivo
Currently available culture conditions do not prevent spontaneous differentiation of leukemic stem cells (LSCs), which greatly limits the feasibility of cell-based assays. To overcome these constraints investigators conducted a high-throughput chemical screen and identified small molecules that inhibit differentiation and support LSC activity in vitro. [Nat Methods] Abstract
Robust Growth of Human Mammary Luminal & Myoepithelial Cells with Serum-Free EpiCult-C (Human) Request a Free Sample
 
PUBLICATIONS (Ranked by impact factor of the journal)
MicroRNA-146a Directs the Symmetric Division of Snail-Dominant Colorectal Cancer Stem Cells
Scientists showed a reduction of asymmetrical cell division in spheroid-derived colorectal cancer stem cells compared with differentiated cancer cells. [Nat Cell Biol] Abstract

Analysis of the Tumor-Initiating and Metastatic Capacity of PDX1-Positive Cells from the Adult Pancreas
The authors sought to determine which subsets of pancreatic and duodenal homeobox 1 (PDX1)+ cells may be responsible for tumor growth. Using the Lox-Stop-Lox-KrasG12D genetic mouse model of pancreatic carcinogenesis, they isolated a population of KrasG12D-expressing PDX1+ cells with an inherent capacity to metastasize. [Proc Natl Acad Sci USA] Abstract

Effect of Niclosamide on Basal-Like Breast Cancers
Aldehyde dehydrogenase (ALDH) is a known marker of cancer stem cells. By testing basal-like breast cancer cells for ALDH expression by flow cytometry, investigators were able to isolate a non-adherent population of cells that have high ALDH expression. [Mol Cancer Ther] Abstract

Patients with CD133-Negative Colorectal Liver Metastasis Have a Poor Prognosis after Hepatectomy
Resected specimens were obtained surgically from 1998 to 2008 at a university hospital. Researchers investigated whether the status of two primary lesion cancer stem biomarkers, CD44 and CD133, were maintained in liver metastasis (L-Mets) and whether these markers were L-Mets prognostic factors. [Ann Surg Oncol] Abstract

ER-α36-Mediated Rapid Estrogen Signaling Positively Regulates ER-Positive Breast Cancer Stem/Progenitor Cells
Researchers investigated the function and the underlying mechanism of 36 kDa full-length estrogen receptor-α (ER-α36)-mediated rapid estrogen signaling in growth regulation of the ER-positive breast cancer stem/progenitor cells. [PLoS One] Full Article

USP22 Is a Positive Regulator of NFATc2 on Promoting IL2 Expression
Investigators showed that ubiquitin-specific protease 22 (USP22), known as a cancer stem cell marker, specifically interacted with and deubiquitinated nuclear factor of activated T cells, cytoplasmic 2 (NFATc2). [FEBS Lett] Abstract

The NFκB Inhibitor, SN50, Induces Differentiation of Glioma Stem Cells and Suppresses Their Oncogenic Phenotype
Scientists show that SN50, a cell-permeable peptide inhibitor of NFκB, induced robust differentiation of human glioma stem-like cells, causing loss of their oncogenic potential. [Cancer Biol Ther] Full Article

Knockdown of 14-3-3ζ Enhances Radiosensitivity and Radio-Induced Apoptosis in CD133+ Liver Cancer Stem Cells
Researchers investigated whether silencing 14-3-3ζ affects the radioresistance of cancer stem-like cells (CSCs) in hepatocellular carcinoma. Knockdown of 14-3-3ζ decreased cell viability and the number of spheres by reducing radioresistance in CSCs after γ-irradiation. [Exp Mol Med] Full Article

Video Protocol: Mucociliary Differentiation of Primary Bronchial Epithelial Cells
 
REVIEWS
p53: The Barrier to Cancer Stem Cell Formation
The authors address the role of p53 in genomically stable embryonic stem cells, a unique predisposed cancer stem cell model and adult stem cells, its role in the generation of induced pluripotent stem cells, as well as its role as the barrier to cancer stem cell formation. [FEBS Lett] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.
 
INDUSTRY NEWS
Verastem Acquires Rights to Cancer Stem Cell Inhibitor VS-4718
Verastem, Inc. announced that it has acquired the license to VS-4718 held originally by Poniard Pharmaceuticals. VS-4718 is an oral compound designed to target cancer stem cells through the potent inhibition of focal adhesion kinase. [Verastem, Inc.] Press Release

OncoMed Pharmaceuticals Commences Third Phase Ib Clinical Trial for OMP-54F28 (Fzd8-Fc) with Carboplatin and Paclitaxel in Ovarian Cancer
OncoMed Pharmaceuticals, Inc., a clinical-stage company developing novel therapeutics that target cancer stem cells announced the initiation of patient treatment for its third multi-center Phase Ib clinical trial of OMP-54F28 with carboplatin and paclitaxel in patients with platinum-sensitive ovarian cancer. [OncoMed Pharmaceuticals, Inc.] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Brain Tumors: Biology & Therapy
June 12-13, 2014
Stockholm, Sweden

Visit our events page to see a complete list of events in the cancer stem cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Scientist – Small Cell Lung Cancer Circulating Tumor Cell Derived Explant Tumor Models (Cancer Research UK Manchester Institute)

Faculty Position – Cancer Biology and Evolution (Moffitt Cancer Center & Research Institute)

Postdoctoral Researcher – Molecular Biology and Cancer Research (Washington State University)

Postdoctoral Position – Molecular Mechanisms of Cell Division (Memorial Sloan Kettering Cancer Center)

Postdoctoral Position – Stem Cell Signaling and Epigenetics (Fondazione Istituto Nazionale Genetica Molecolare)

Research Assistant – Stem Cell & Leukemia Epigenetic (King’s College London)

Postdoctoral Fellow – Morphogenetic Signaling Pathways in Development and Disease (University of Rochester Medical Center)

Postdoctoral Research Fellow (Brigham & Women’s Hospital and Harvard Medical School)

Postdoctoral Position – Epigenetics and Cancer Biology (MPI Bad Nauheim)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)


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