Volume 3.06 | Feb 19

Cancer Stem Cell News 3.06 February 19, 2014
Cancer Stem Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Pre-Leukemic Stem Cell at Root of AML, Relapse
Cancer researchers have discovered a pre-leukemic stem cell that may be the first step in initiating disease and also the culprit that evades therapy and triggers relapse in patients with acute myeloid leukemia (AML). [Press release from Princess Margaret Cancer Centre discussing online prepublication in Nature]
Press Release | Abstract
Culture and Characterize Mouse Mammary Epithelial Progenitors with Serum-Free EpiCult-B (Mouse) Free Protocols
 
PUBLICATIONS (Ranked by impact factor of the journal)
Essential Role of BRG, the ATPase Subunit of BAF Chromatin Remodeling Complexes, in Leukemia Maintenance
The authors showed using quantitative proteomics that BAF complexes expressed in leukemia are specifically assembled around the BRG ATPase. Using a mouse model of acute myeloid leukemia, they demonstrated that BRG is essential for leukemia maintenance, as leukemic cells lacking BRG rapidly undergo cell-cycle arrest and apoptosis. [Blood] Abstract | Press Release

Stem Cell Characteristics in Glioblastoma Are Maintained by the Ecto-Nucleotidase E-NPP1
A sub-population of glioblastoma stem-like cells that shares properties with neural precursor cells has been described, exhibiting resistance to therapy and therefore being considered responsible for the high recurrence rate in glioblastoma. [Cell Death Diff] Abstract

SOCS3-Mediated Regulation of Inflammatory Cytokines in PTEN and p53 Inactivated Triple Negative Breast Cancer Model
p53 and PTEN knockdown synergized to activate pro-inflammatory interleukin-6/Stat3/nuclear factor κB signaling. This resulted in generation of highly metastatic epithelial-to-mesenchymal transition-like cancer stem cells resulting in tumors whose gene expression profile mimicked that found in basal/claudin-low molecular subtype within the triple negative breast tumors. [Oncogene] Abstract | Press Release

The TrkB+ Cancer Stem Cells Contribute to Post-Chemotherapy Recurrence of Triple-Negative Breast Cancers in an Orthotopic Mouse Model
Scientists showed that cancer stem cells derived from recurrent triple-negative breast cancers are endowed with increased self-renewal capacity as compared with those from the matched primary lesions. [Oncogene] Abstract

TAZ Is Required for Metastatic Activity and Chemoresistance of Breast Cancer Stem Cells
The authors analyzed a set of patient-derived breast cancer stem cell (BCSC) lines. They found that in vitro BCSCs exhibit a higher chemoresistance and migratory potential when compared with differentiated, nontumorigenic, breast cancer cells. [Oncogene] Abstract

RhoC Regulates Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma by Overexpressing IL-6 and Phosphorylation of STAT3
Scientists investigated the correlation between RhoC expression and cancer stem cells formation in head and neck squamous cell carcinoma (HNSCC). The inhibition of RhoC function was achieved using shRNA. The expression of stem cell surface markers ALDH and CD44 were significantly low in two RhoC depleted HNSCC cell lines. [PLoS One] Full Article

Protein Kinase C-Delta Inactivation Inhibits the Proliferation and Survival of Cancer Stem Cells in Culture and In Vivo
Researchers demonstrate that cancer stem-like cell populations derived from multiple types of human primary tumors, from human cancer cell lines, and from transformed human cells, require protein kinase C delta (PKCδ) activity and are susceptible to agents which deplete PKCδ protein or activity. [BMC Cancer] Full Article

Analysis of Multiple Markers for Cancer Stem-Like Cells in Human Thyroid Carcinoma Cell Lines
Cancer stem-like cells (CSCs) have been isolated using several markers, but those for thyroid CSCs remain to be confirmed. Investigators conducted a comprehensive search for thyroid CSC markers. [Endocr J]
Abstract | Full Article

Spatial Distribution of Cancer Stem Cells in Head and Neck Squamous Cell Carcinomas
Investigators evaluated the patterns of CD44 and aldehyde dehydrogenase 1 expression in the tumor center and in the invasive front, as well as in adjacent non-tumor epithelium, and correlated these findings with clinical parameters. [J Oral Pathol Med] Abstract

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Culture Human Glioma-Derived Tumorspheres with NeuroCult™ - View Publications
 
REVIEWS
Dedifferentiation and Reprogramming: Origins of Cancer Stem Cells
The authors discuss the similarities between tumor dedifferentiation and somatic cell reprogramming and how this may pose a risk to the application of this new technology in regenerative medicine. [EMBO Rep] Abstract

Cell Adhesion Molecules and Their Relation to (Cancer) Cell Stemness
The authors draw comparison between reprogramming and carcinogenesis, as well as between stem cells and cancer stem cells, focusing on changing garniture of adhesion molecules. [Carcinogenesis] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

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INDUSTRY NEWS
California Stem Cell Announces U.S. FDA Approval of Phase II Cancer Stem Cell Clinical Trial for Ovarian Cancer
California Stem Cell, Inc. announced that the U.S. Food and Drug Administration (FDA) has approved the Company’s application to begin a Phase II clinical trial exploring the potential of a patient-specific cancer immunotherapy in women with stage III or IV ovarian, fallopian tube or primary peritoneal cancer. [California Stem Cell, Inc.] Press Release

OncoMed Pharmaceuticals Initiates Second Phase Ib Clinical Trial for OMP-54F28 (Fzd8-Fc) with Sorafenib (Nexavar®) in Hepatocellular Cancer
OncoMed Pharmaceuticals, Inc., a clinical-stage company developing novel therapeutics that target cancer stem cells, announced that it has started a multi-center Phase Ib clinical trial of OMP-54F28 (Fzd8-Fc) with sorafenib (Nexavar®) in hepatocellular cancer. [OncoMed Pharmaceuticals, Inc.] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW 12th Cancer Immunotherapy (CIMT) Annual Meeting “Next Waves in Cancer Immunotherapy”
May 5-8, 2014
Mainz, Germany

Visit our events page to see a complete list of events in the cancer stem cell community.
 
JOB OPPORTUNITIES
NEW Faculty Position – Cancer Biology and Evolution (Moffitt Cancer Center & Research Institute)

NEW Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

NEW Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

NEW Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

Postdoctoral Researcher – Molecular Biology and Cancer Research (Washington State University)

Postdoctoral Position – Molecular Mechanisms of Cell Division (Memorial Sloan Kettering Cancer Center)

Postdoctoral Position – Stem Cell Signaling and Epigenetics (Fondazione Istituto Nazionale Genetica Molecolare)

Research Assistant – Stem Cell & Leukemia Epigenetic (King’s College London)

Postdoctoral Fellow – Morphogenetic Signaling Pathways in Development and Disease (University of Rochester Medical Center)

Postdoctoral Research Fellow (Brigham & Women’s Hospital and Harvard Medical School)

Postdoctoral Position – Epigenetics and Cancer Biology (MPI Bad Nauheim)


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