Volume 3.04 | Feb 5

Cancer Stem Cell News 3.04 February 5, 2014
Cancer Stem Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Long-Lived Intestinal Tuft Cells Serve as Colon Cancer-Initiating Cells
Doublecortin-like kinase 1 protein (DCLK1)+ tuft cells are increased in inflammation-induced carcinogenesis; however, the role of these cells within the gastrointestinal epithelium and their potential as cancer-initiating cells are poorly understood. Here, using a BAC-CreERT-dependent genetic lineage-tracing strategy, scientists determined that a subpopulation of DCLK1+ cells is extremely long lived and possesses rare stem cell abilities. [J Clin Invest] Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
Smac Mimetic Promotes Glioblastoma Cancer Stem-Like Cell Differentiation by Activating NF-?B
Investigators identified a novel function of BV6 in regulating differentiation of glioblastoma cancer stem-like cells by activating NF-?B. [Cell Death Differ] Abstract

EphA2 Promotes Infiltrative Invasion of Glioma Stem Cells In Vivo through Cross-Talk with Akt and Regulates Stem Cell Properties
Using human glioma stem cells that recapitulate the invasive propensity of primary glioblastoma multiforme (GBM), scientists found that EphA2 critically regulates GBM invasion in vivo. [Oncogene] Abstract

Roles of Wnt/ß-Catenin Signaling in the Gastric Cancer Stem Cells Proliferation and Salinomycin Treatment
Stable overexpression of Wnt1 increased AGS gastric cancer cells’ proliferation rate and spheroids formation, which expressed cancer stem cell surface markers Oct4 and CD44. [Cell Death Dis] Full Article

Hypoxia Increases Gefitinib-Resistant Lung Cancer Stem Cells through the Activation of Insulin-Like Growth Factor 1 Receptor
Researchers elucidated the role of hypoxia and cancer stem cells in the resistance to gefitinib in non-small cell lung cancer with activating epidermal growth factor receptor mutation. [PLoS One] Full Article

Characterization of Fenofibrate-Mediated Anti-Proliferative Pro-Apoptotic Effects on High-Grade Gliomas and Anti-Invasive Effects on Glioma Stem Cells
Investigators characterized the effects of peroxisome proliferator-activated receptor-a agonist, fenofibrate, directly on high-grade glioma cells and glioma stem cells. [J Neurooncol] Abstract

Mesenchymal Stem Cells Show Little Tropism for the Resting and Differentiated Cancer Stem Cell-Like Glioma Cells
Scientists obtained homologous bone marrow-derived (BM-) and adipose tissue-derived (AT-) mesenchymal stem cells (MSCs), fibroblast, and cancer stem cell-like glioma cells (CSGCs) from tumor-bearing mice, and compared the tropism character of BM- and AT-MSCs for CSGCs with various form of existence. [Int J Oncol] Abstract

Nestin Regulates Proliferation, Migration, Invasion and Stemness of Lung Adenocarcinoma
Nestin is thought to regulate tumor cell proliferation, migration, invasion and cancer stem cell properties. High and moderate expression levels of nestin were confirmed in several lung adenocarcinoma cell lines including H1975 and PC-3. [Int J Oncol] Abstract

OCT3 and SOX2 Promote the Transformation of Barrett’s Esophagus to Adenocarcinoma by Regulating the Formation of Tumor Stem Cells
Researchers observed that the expressions of Octamer transcription factor (OCT)-3/4, SOX2, TCL1 and AKT1 in Barrett’s esophagus were elevated compared to normal esophagus but were decreased compared to esophagus adenocarcinoma. Moreover, they isolated a few stem-like cells in OE33 cells which showed similar biological behavior to tumor stem cells. [Oncol Rep] Abstract

A Niche-Like Culture System Allowing the Maintenance of Primary Human Acute Myeloid Leukemia-Initiating Cells: A New Tool to Decipher Their Chemoresistance and Self-Renewal Mechanisms
Scientists report that by modeling key elements of the bone marrow niche using different stromal feeder layers and hypoxic culture conditions, they can maintain leukemia-initiating cells over at least three weeks and support their self-renewal properties demonstrated through primary and secondary successful xenograft. [Stem Cells Transl Med] Abstract

Hes1 Is Involved in the Self-Renewal and Tumorigenicity of Stem-Like Cancer Cells in Colon Cancer
Researchers found upregulated Hes1 in poorly differentiated cancer samples compared with well-differentiated tumor samples, and most of the adenocarcinomas exhibited significantly higher levels of Hes1 mRNA compared with that observed in matched normal colon samples. [Sci Rep] Full Article

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Culture Human Glioma-Derived Tumorspheres with NeuroCult™ - View Publications
 
REVIEWS
Role of p75 Neurotrophin Receptor in Stem Cell Biology: More than Just a Marker
The authors give an overview of the current knowledge on p75NTR in stem cells, ranging from embryonic to adult stem cells, and cancer stem cells. In an attempt to address its potential role in the control of stem cell biology, the molecular mechanisms underlying p75NTR signaling in different models are also highlighted. [Cell Mol Life Sci] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.
 
INDUSTRY NEWS
Verastem Issued Japanese Patent on Dual mTORC1/2 and PI3K Inhibitor VS-5584
Verastem, Inc., focused on discovering and developing drugs to treat cancer by the targeted killing of cancer stem cells, announced that it has been issued a patent by the Japanese Patent Office for the company’s small molecule dual inhibitor of mTORC1/2 and PI3K VS-5584. [Verastem, Inc.] Press Release

Stem Cell Agency Funds More Than $66 Million in Research Including New Genomics Initiative
A team bringing together experts and investigators from seven different major California institutions has been awarded $40 million to create a new Center of Excellence in Stem Cell Genomics, by California’s stem cell agency, the California Institute for Regenerative Medicine. [California Institute for Regenerative Medicine]
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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW The Stem Cell Niche 2014
May 18-22, 2014
Copenhagen, Denmark

Visit our events page to see a complete list of events in the cancer stem cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Position – Molecular Mechanisms of Cell Division (Memorial Sloan Kettering Cancer Center)

NEW Lab Technologist – Human Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Postdoctoral Position – Stem Cell Signaling and Epigenetics (Fondazione Istituto Nazionale Genetica Molecolare)

Research Assistant – Stem Cell & Leukemia Epigenetic (King’s College London)

Postdoctoral Fellow – Morphogenetic Signaling Pathways in Development and Disease (University of Rochester Medical Center)

Postdoctoral Research Fellow (Brigham & Women’s Hospital and Harvard Medical School)

Postdoctoral Position – Epigenetics and Cancer Biology (MPI Bad Nauheim)

PhD Candidates – Stem Cells and Biomedical Engineering (Queensland University of Technology)

Postdoctoral Position – Stem Cells and Bioengineering (Queensland University of Technology/Translational Research Institute)


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