Volume 2.37 | Sep 18

Cancer Stem Cell News 2.37 September 18, 2013
Cancer Stem Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Protein Kinase C α Is a Central Signaling Node and Therapeutic Target for Breast Cancer Stem Cells
Researchers report that inhibition of protein kinase C α (PKCα) specifically targets cancer stem cells (CSCs) but has little effect on non-CSCs. The formation of CSCs from non-stem cells involves a shift from EGFR to PDGFR signaling and results in the PKCα-dependent activation of FRA1. [Cancer Cell] Abstract | Graphical Abstract
Culture Human Glioma-Derived Tumorspheres with NeuroCult™ - View Publications
 
PUBLICATIONS (Ranked by impact factor of the journal)
The Large Intergenic Noncoding RNA Hotair Is Required for Epithelial-to-Mesenchymal Transition and Stemness Maintenance of Cancer Cells Lines
The authors investigated the role of Hotair in the scenario of epithelial-to-mesenchymal transition (EMT) and in the arising and maintenance of cancer stem cells. They found that treatment with TGF-β1 resulted in increased Hotair expression and triggered the EMT program. [Stem Cells] Abstract

Leptin Receptor Maintains Cancer Stem-Like Properties in Triple Negative Breast Cancer Cells
The authors previously showed that the adipose tissue cytokine LEPTIN, increased in obesity, promotes the survival of cancer stem cells (CSCs) in vivo.In this study, they tested the hypothesis that the Leptin Receptor, expressed in mammary cancer cells, is necessary for maintaining CSC-like and metastatic properties. [Endocr Relat Cancer] Abstract

Slug/β-Catenin-Dependent Proinflammatory Phenotype in Hypoxic Breast Cancer Stem Cells
Investigators observed that hypoxic bone marrow stroma-derived transforming growth factor-β 1 promotes the growth of human breast cancer stem cells as mammospheres. [Am J Pathol] Abstract

SOX2 Plays a Critical Role in EGFR-Mediated Self-Renewal of Human Prostate Cancer Stem-Like Cells
Researchers report a significant upregulation of SOX2 at both mRNA and protein levels in DU145 prostate cancer stem cells (PCSCs) propagated as suspension spheres in vitro. The expression of SOX2 in DU145 PCSCs is positively regulated by epidermal growth factor receptor (EGFR) signaling. [Cell Signal] Abstract

Concomitant Targeting of Multiple Key Transcription Factors Effectively Disrupts Cancer Stem Cells Enriched in Side Population of Human Pancreatic Cancer Cells
Investigators identified side population cells and characterized s-like properties in human pancreatic cancer cell lines and to exploit the efficacy of concomitant targeting of multiple key transcription factors governing the stemness of pancreatic cancer stem cells (CSCs) in suppressing CSC-like phenotypes. [PLoS One]
Full Article

Epithelial-Mesenchymal Transition Associates with Maintenance of Stemness in Spheroid-Derived Stem-Like Colon Cancer Cells
Despite earlier studies demonstrating characteristics of colon cancer stem cells (CCSCs) and the role of epithelial-mesenchymal transition (EMT) in tumor development, it remains controversial as to the relationship between CCSCs and EMT. In order to present an insight into this relationship in colon cancer, scientists developed HCT116 and HT29 sphere models, which are known to be the cells enriching cancer stem cells. [PLoS One] Full Article

Treatment of Agarose-Agarose RENCA Macrobeads with Docetaxel Selects for OCT4+ Cells with Tumor-Initiating Capability
The authors recently described the niche-like nature of mouse renal adenocarcinoma (RENCA) cells following encapsulation in agarose macrobeads. In this paper they tested the hypothesis that encapsulated RENCA colonies function as an in vitro model of a cancer stem cell niche and that the majority of cells would undergo chemotherapy-induced death, followed by tumor recurrence. [Cancer Biol Ther]
Abstract | Full Article

Energy Metabolism Characterization of a Novel Cancer Stem Cell-Like Line 3AB-OS
Investigators aimed to comparatively analyze bioenergetics features of the human osteosarcoma 3AB-OS cancer stem cell-like line, and the parental osteosarcoma MG63 cells, from which 3AB-OS cells have been previously selected. [J Cell Biochem] Abstract

Water Bath Hyperthermia Reduces Stemness of Colon Cancer Cells
Side population (SP) cells are part of a subpopulation of cells that have stem cell-like characteristics. In preliminary experiments, scientists discovered a decrease in SP cells in heat-treated colon cancer cells, which encouraged them to investigate whether hyperthermia had in fact played a role in regulating the stemness of colon cancer cells. [Clin Biochem] Abstract

Listen Now: New Podcast on ALDH in Breast Cancer Treatment Response
 
REVIEWS
Metastatic Mechanism in Follicular Cell-Derived Thyroid Cancer
The direct targets of activity in metastatic lesions are incompletely defined and clear evidence that these treatments increase the duration or quality of life of patients is lacking, underscoring the need for improved knowledge regarding the metastatic process to inform the development of new therapies. In this review, the authors focus on current data and hypotheses regarding key regulators of metastatic dormancy, metastatic progression, and the role of putative cancer stem cells. [Endocr Relat Cancer] Abstract | Full Article

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.
 
INDUSTRY NEWS
Weill Cornell Medical College Receives $100 Million Gift from Joan and Sanford I. Weill and the Weill Family Foundation to Launch New Capital Campaign
Weill Cornell Medical College announced that it has received a $100 million gift from longtime benefactors Joan and Sanford I. Weill and the Weill Family Foundation to launch the Medical College’s $300 million Driving Discoveries, Changing Lives campaign dedicated to using the most advanced scientific approaches to rapidly translate research breakthroughs into innovative treatments and therapies for patients. [Weill Cornell Medical College] Press Release

Cell Therapy Catapult & Roslin Cells to Create Clinical Grade Stem Cells to Accelerate Research into New Treatments
The Cell Therapy Catapult, which is focused on the development of the UK cell therapy industry to increase the nation’s health and wealth, and Roslin Cells, an expert in the production of stem cells, are partnering to establish a source of clinical grade induced pluripotent stem cells banked according to Good Manufacturing Practice in the UK. [Roslin Cells] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Keystone Symposia: Stem Cells and Cancer
February 2-7, 2014
Banff, Canada

Visit our events page to see a complete list of events in the cancer stem cell community.
 
JOB OPPORTUNITIES
NEW Research Associate – Leukemia & Stem Cell Biology (King’s College London)

Tenure Track Faculty Positions – Cancer Biology (Memorial Sloan-Kettering Cancer Center)

Assistant Professor – Developmental and Stem Cell Biology (METU Department of Biology)

Principal Scientist – Cancer Stem Cells (Pharma Professionals Europe Ltd)

Postdoctoral Fellowships – Cancer Stem Cell Biology and Pharmacogenomics (Biotech Research & Innovation Center, University of Copenhagen)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Postdoctoral Appointee – Cell Cycle Regulation in Tumor Stem Cells (Rutgers University, Rutgers Cancer Institute of New Jersey)

Research Technician – Self-Renewal of Cancer Stem Cells (University of Chicago)


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