Volume 2.24 | Jun 19

Cancer Stem Cell News 2.24 June 19, 2013
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     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Oncofetal Gene SALL4 in Aggressive Hepatocellular Carcinoma
Researchers screened specimens obtained from patients with primary hepatocellular carcinoma for the expression of SALL4 and carried out a clinicopathological analysis. Gene-expression analysis showed the enrichment of progenitor-like gene signatures with overexpression of proliferative and metastatic genes in SALL4-positive hepatocellular carcinomas. Loss-of-function studies confirmed the critical role of SALL4 in cell survival and tumorigenicity. [N Engl J Med] Abstract | Press Release

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PUBLICATIONS (Ranked by impact factor of the journal)

Molecular Profiling of Human Mammary Gland Links Breast Cancer Risk to a p27+ Cell Population with Progenitor Characteristics
Early full-term pregnancy is one of the most effective natural protections against breast cancer. The authors found significant differences in CD44+ progenitor cells, where the levels of many stem cell-related genes and pathways, including the cell-cycle regulator p27, are lower in parous women without BRCA1/BRCA2 mutations. [Cell Stem Cell] Abstract | Graphical Abstract

Lineage Tracing Reveals Multipotent Stem Cells Maintain Human Adenomas and the Pattern of Clonal Expansion in Tumor Evolution
Researchers identified multipotential stem cells within human colorectal adenomas and use methylation patterns of nonexpressed genes to characterize clonal evolution. [Proc Natl Acad Sci USA] Abstract

PPARγ Maintains ERBB2-Positive Breast Cancer Stem Cells
Results show that the peroxisome proliferator-activated receptor-γ (PPARγ) pathway is critical for the cancer stem cell properties of ERBB2-positive breast cancer cells. [Oncogene] Full Article

The Pluripotency Factor Nanog Promotes Breast Cancer Tumorigenesis and Metastasis
To elucidate the physiological roles of Nanog in tumorigenesis, researchers developed an inducible Nanog transgenic mouse model, in which the expression of Nanog in adult tissues can be induced via LoxP/Cre-mediated deletion. Their findings indicate that overexpression of Nanog in the mammary gland is not sufficient to induce mammary tumor. However, when coexpressed with Wnt-1 in the mouse mammary gland, it promotes mammary tumorigenesis and metastasis. [Oncogene] Abstract

IMP1 Promotes Tumor Growth, Dissemination, and a Tumor-Initiating Cell Phenotype in Colorectal Cancer Cell Xenografts
Scientists demonstrate that Igf2 mRNA binding protein 1 (IMP1) overexpression decreases E-cadherin expression, promotes survival of single tumor cell-derived colonospheres, and promotes enrichment and maintenance of a population of CD24+CD44+ cells, signifying that IMP1 overexpressing cells display evidence of loss of epithelial identity as well as enhancement of a tumor-initiating cell phenotype. [Carcinogenesis] Abstract

Metalloproteinase-Disintegrin ADAM12 Is Associated with a Breast Tumor-Initiating Cell Phenotype
Researchers found that ADAM12L, but not the alternative splice variant ADAM12S, is a part of stromal, mammosphere, and epithelial-to-mesenchymal transition gene signatures, which are all associated with breast tumor-initiating cells. [Breast Cancer Res Treat] Abstract

Identification of Cancer Stem-Like Side Population Cells in Purified Primary Cultured Human Laryngeal Squamous Cell Carcinoma Epithelia
Findings suggest that the primary cultured and purified laryngeal squamous cell carcinoma cells (LSCCs) contain cancer stem-like side population cells, which may serve as a valuable model for cancer stem cell research in LSCC. [PLoS One] Full Article

Pulmonary Fibroblasts Induce Epithelial Mesenchymal Transition and Some Characteristics of Stem Cells in Non-Small Cell Lung Cancer
Investigators aimed to clarify the role of fibroblasts in tumor progression in non-small cell lung cancer (NSCLC). Fibroblasts were associated with increased malignant potential and the acquisition of stemness in NSCLC tumors. [Ann Thorac Surg] Abstract

Listen Now: New Podcast on ALDH in Breast Cancer Treatment Response
REVIEWS
The Evolution of the Cancer Niche during Multistage Carcinogenesis
The authors propose the novel concept that the tumor microenvironment is built through rate-limiting steps during multistage carcinogenesis. Construction of a ‘precancer niche’ is a necessary and early step that is required for initiated cells to survive and evolve; subsequent niche expansion and maturation accompany tumor promotion and progression, respectively. [Nat Rev Cancer] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

MSC 2013 - Adult Stem Cell Therapy & Regenerative Medicine
INDUSTRY NEWS
Verastem Receives Orphan Medicinal Product Designation from the European Commission for VS-6063 in Mesothelioma
Verastem, Inc. announced that VS-6063 has received orphan medicinal product designation from the European Commission for use in mesothelioma. The designation is to encourage the development of drugs which may provide significant benefit to patients suffering from rare diseases. [Verastem, Inc.]
Press Release

Immune Design Partners with Leading Cancer Organizations to Advance Novel Immunotherapy Research
The Cancer Research Institute, the Ludwig Institute for Cancer Research and Immune Design announced that they have signed a collaboration agreement to advance cancer immunotherapy research. Specifically, the partnership will focus on clinical trials to test novel combinations of immunotherapies, including two investigational drugs from Immune Design’s pipeline. [Ludwig Institute For Cancer Research Ltd]
Press Release

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POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

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EVENTS

NEW World Cord Blood Congress 2013
September 30-October 1, 2013
Cambridge, United States

NEW Cell Culture World Congress USA 2013
September 30-October 1, 2013
Cambridge, United States

NEW Stem Cells & Regenerative Medicine Congress 2013
September 30-October 1, 2013
Cambridge, United States

Visit our
events page to see a complete list of events in the cancer stem cell community.

JOB OPPORTUNITIES

NEW Postdoctoral Position – Molecular and Cellular Oncology (VIB Department for Molecular Biomedical Research, University of Ghent)

Director of Cell Processing Facility (S L Collins Associates, Inc.)

Postdoctoral Fellow – Cancer Biology and Stem Cell (University of Texas Health Science Center at Houston)

Postdoctoral Position – Breast Cancer/Stem Cell Biology (University of Cincinnati College of Medicine)

Postdoctoral Associate – Salivary Gland Cancers (Yale School of Medicine)

Postdoctoral Fellow – Stem Cells and Cancer (Tsinghua University)

Postdoctoral Fellow – Stem Cell and Cancer Biology (Johns Hopkins University School of Medicine)

Postdoctoral Fellow – Stem Cells and Cancer (Albert Einstein College of Medicine)

PhD Studentship Opportunity – Tumor-Initiating Melanoma Cells (University of East Anglia)


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