Volume 2.21 | May 29

Cancer Stem Cell News 2.21 May 29, 2013
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TOP STORY
Connective Tissue Growth Factor Activates Pluripotency Genes and Mesenchymal-Epithelial Transition in Head and Neck Cancer Cells
Researchers demonstrated that in head and neck squamous cell carcinoma (HNSCC), connective tissue growth factor (CTGF) promotes the mesenchymal-epithelial transition and reduces invasiveness. Moreover, they found that CTGF enhances the stem-like properties of HNSCC cells and increases the expression of multiple pluripotency genes. [Cancer Res] Abstract

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PUBLICATIONS (Ranked by impact factor of the journal)

Gene Expression Classification of Colon Cancer into Molecular Subtypes: Characterization, Validation, and Prognostic Value
Investigators aimed to establish a comprehensive molecular classification of colon cancer based on mRNA expression profile analyses. Based on their main biological characteristics, they distinguished a deficient mismatch repair subtype, a KRAS mutant subtype, a cancer stem cell subtype, and three chromosomal instability subtypes, including one associated with down-regulated immune pathways, one with up-regulation of the Wnt pathway, and one displaying a normal-like gene expression profile. [PLoS Med] Full Article

Somatic Loss of P53 Leads to Stem/Progenitor Cell Amplification in Both Mammary Epithelial Compartments, Basal and Luminal
Results strongly indicate that p53 restricts the propagation and self-renewal of stem/progenitor cells in both layers of the mammary epithelium providing further insight into the impact of p53 loss in breast cancerogenesis. [Stem Cells] Abstract

Prolactin Suppresses a Progestin-Induced CK5-Positive Cell Population in Luminal Breast Cancer through Inhibition of Progestin-Driven BCL6 Expression
In luminal breast cancer, progesterone induces a cytokeratin-5 (CK5)-positive basal cell-like population. This population possesses characteristics of tumor stem cells including quiescence, therapy resistance and tumor-initiating capacity. Researchers reported that prolactin counteracts induction of the CK5-positive population by the synthetic progestin R5020 in luminal breast cancer cells both in vitro and in vivo. [Oncogene] Abstract

Phosphorylation of Nanog Is Essential to Regulate Bmi1 and Promote Tumorigenesis
Human Nanog was identified to be phosphorylated by human protein kinase Cε at multiple residues, including T200 and T280. This work indicated that phosphorylation at T200 and T280 modulates Nanog function through several regulatory mechanisms. Ectopic expression of phosphorylation-insensitive T200A or T280A mutant Nanog reduced cell proliferation, colony formation, invasion, migration and the cancer-initiating cell population in head and neck squamous cell carcinoma cells. [Oncogene] Abstract

MicroRNA-21 Regulates the Migration and Invasion of a Stem-Like Population in Hepatocellular Carcinoma
Scientists identified and isolated populations of side population (SP) cells from hepatocellular carcinoma (HCC) cell lines using flow cyto­metry. SP cells showed higher levels of migration and invasion capability. Higher expression of microRNA (miR)-21 was observed in SP cells. Silencing of miR-21 led to a reduction in the migration and invasion of these cells and overexpression of miR-21 can increase cell migration and invasion. [Int J Oncol] Abstract

Implantation of GL261 Neurospheres into C57/BL6 Mice: A More Reliable Syngeneic Graft Model for Research on Glioma-Initiating Cells
Whether animal models can mimic the cellular microenvironment of malignancy and evaluate the biological features of glioma-initiating cells accurately is unclear. Researchers detected the biological features of neurosphere-like tumor cells derived from the murine glioblastoma (GBM) cell line GL261 (GL261-NS) and from primary human GBM (PGBM-NS) in vitro, injected GL261-NS into syngeneic C57/BL6 mouse brain and injected PGBM-NS into NOD/SCID mouse brain, respectively. [Int J Oncol] Abstract

An Aberrant Transcription Factor Network Essential for Wnt Signaling and Stem Cell Maintenance in Glioblastoma
Investigators presented a comparative analysis of chromatin state in glioblastoma cancer stem cells that reveals widespread activation of genes normally held in check by Polycomb repressors. [Cell Rep]
Abstract | Full Article | Graphical Abstract

CD133+ Subpopulation of the HT1080 Human Fibrosarcoma Cell Line Exhibits Cancer Stem-Like Characteristics
CD133+ cells were obtained and characterized from the HT1080 cell line to determine the utility of this marker for isolating cancer stem cells from human fibrosarcoma cells. [Oncol Rep] Abstract

Free Wallchart from Nature Neuroscience: Neural Stem Cells

REVIEWS
Crosstalk between Breast Cancer Stem Cells and Metastatic Niche: Emerging Molecular Metastasis Pathway?
The authors hypothesize the presence of a possible emerging molecular pathway in the biological process of breast cancer metastasis. In this process, non-Smad TGF-β-induced metastasis connects cancer stem cell and metastatic niche formation through a central path, “Metastasis Pathway”. [Tumor Biol] Abstract

Visit our reviews page to see a complete list of reviews in the cancer stem cell research field.

SMi's Cell Culture Conference July 3-4, 2013 in London, United Kingdom
INDUSTRY NEWS

Cambridge Scientists’ Mission to Destroy Cancer ‘Queen Bees’
A team of University of Cambridge scientists has been granted £390,000 by the blood cancer charity Leukaemia & Lymphoma Research to develop ways of attacking types of cancer cells described as the ‘queen bees’ of childhood lymphoma. [Leukaemia & Lymphoma Research] Press Release

Lyda Hill Commits $50 Million to Moon Shots Program
Lyda Hill, of Dallas, has pledged $50 million to The University of Texas MD Anderson Cancer Center’s Moon Shots Program, an unprecedented, comprehensive assault on cancer announced in September 2012. [The University of Texas MD Anderson Cancer Center] Press Release

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POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)
 
European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

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EVENTS
NEW American Association for Cancer Research (AACR): Frontiers in Basic Cancer Research
September 18-22, 2013
National Harbor, United States

Visit our
events page to see a complete list of events in the cancer stem cell community.
JOB OPPORTUNITIES

NEW Postdoctoral Position – Breast Cancer/Stem Cell Biology (University of Cincinnati College of Medicine)

Postdoctoral Associate – Salivary Gland Cancers (Yale School of Medicine)

Postdoctoral Fellow – Stem Cells and Cancer (Tsinghua University)

Postdoctoral Fellow – Stem Cell and Cancer Biology (Johns Hopkins University School of Medicine)

Postdoctoral Position – Tumor Microenvironment & Pancreatic Cancer (INSERMU1068)

Postdoctoral Fellow – Stem Cells and Cancer (Albert Einstein College of Medicine)

PhD Studentship Opportunity – Tumor-Initiating Melanoma Cells (University of East Anglia)

Faculties in Cancer Biology & Immunotherapy (Huzhou University School of Medicine)


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