Volume 2.11 | Mar 20

Cancer Stem Cell News 2.11 March 20, 2013
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     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Ablation of Fbxw7 Eliminates Leukemia-Initiating Cells by Preventing Quiescence
The authors showed that Fbxw7 plays a pivotal role in maintenance of quiescence in leukemia-initiating cells of chronic myeloid leukemia by reducing the level of c-Myc. [Cancer Cell] Abstract | Graphical Abstract

Culture Human Glioma-Derived Tumorspheres with NeuroCult™ - View Publications

PUBLICATIONS (Ranked by impact factor of the journal)

Regulation of c-Myc Ubiquitination Controls Chronic Myelogenous Leukemia Initiation and Progression
Investigators used chronic myelogenous leukemia as a model of leukemia-initiating cell (LIC)-dependent malignancy and identify the interaction between the ubiquitin ligase Fbw7 and its substrate c-Myc as a regulator of LIC homeostasis. [Cancer Cell] Abstract

Depletion of Jak2V617F MPN-Propagating Stem Cells by Interferon-Alpha in a Murine Model of Polycythemia Vera
Using a murine model of Jak2V617F myeloproliferative neoplasms (MPN), researchers investigated the effects of interferon alpha on Jak2V617F MPN-propagating stem cells in vivo. [Blood]
Abstract | Press Release

Critical Role of miR-9 in Myelopoiesis and EVI1-Induced Leukemogenesis
Results revealed a unique role of microRNA-9 (miR-9) in myelopoiesis and in the pathogenesis of ecotropic viral integration site 1 (EVI1)-induced myeloid neoplasms and provide insights into the epigenetic regulation of miR9 in tumorigenesis. [Proc Natl Acad Sci USA] Abstract

A Distinct Reactive Oxygen Species Profile Confers Chemoresistance in Glioma-Propagating Cells and Associates with Patient Survival Outcome
Researchers explored the role of elevated O2-:H2O2 ratio as a prosurvival signal in glioma-propagating cells (GPCs). They hypothesized that depleting this ratio sensitizes GPCs to apoptotic triggers. [Antioxid Redox Signal] Abstract

Novel HSP90 Inhibitor NVP-HSP990 Targets Cell Cycle Regulators to Ablate Olig2-Positive Glioma Tumor Initiating Cells
The authors evaluated the effects of a novel HSP90 inhibitor, NVP-HSP990, in glioma tumor initiating cell populations, which are strongly implicated in the root pathobiology of glioblastoma multiforme. [Cancer Res] Abstract

ShRNA Targeting Notch1 Sensitizes Breast Cancer Stem Cell to Paclitaxel
Researchers confirmed that paclitaxel enriched breast cancer stem cells (CSCs) in a dose-dependent manner in MCF-7 human breast cancer cell line. They then demonstrated that Notch1 was overexpressed in breast CSCs isolated from paclitaxel-treated MCF-7 cells compared to non-CSCs. The short hairpin RNA (shRNA) mediated knock-down of Notch1 inhibited MCF-7 cell proliferation and induced cell apoptosis. [Int J Biochem Cell Biol] Abstract

Lin28a Is a Putative Factor in Regulating Cancer Stem Cell-Like Properties in Side Population Cells of Oral Squamous Cell Carcinoma
Investigators identified side population cells, which are known to be an enriched population of cancer stem cells, in five oral squamous cell carcinoma cells. [Exp Cell Res] Abstract

Increased In Vivo Angiogenic Effect of Glioma Stromal Mesenchymal Stem-Like Cells on Glioma Cancer Stem Cells from Patients with Glioblastoma
Scientists investigated the biological effects of glioma stromal mesenchymal stem-like cells (GS-MSLCs) on glioma cancer stem cells (gCSCs), testing the hypothesis that GS-MSLCs alter the biological characteristics of gCSCs. [Int J Oncol] Abstract

Association of Gankyrin and Stemness Factor Expression in Human Colorectal Cancer
Researchers investigated the expression of gankyrin and stemness factors in human colorectal adenomas, precancerous lesions, as well as colorectal cancer tissues to assess its involvement in colorectal carcinogenesis. [Dig Dis Sci] Abstract

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INDUSTRY NEWS

Dicerna Announces Patent Issuance for Dicer Substrate siRNA Directed at the KRAS Gene, a Key Cancer Regulator
Dicerna Pharmaceuticals, Inc. announced that the United States Patent and Trademark Office has issued patent claims specific to double-stranded RNAs directed against the important oncology gene target KRAS. [Dicerna Pharmaceuticals, Inc.] Press Release

NW Bio Receives U.S. Patent on Broad Processes for Producing More Potent Dendritic Cells
Northwest Biotherapeutics (NW Bio) announced that it has been issued a key U.S. patent (#8389278) covering novel processes for manufacturing human dendritic cells. The cells produced through these processes are much more potent in their capacity to activate the immune system than those produced by the standard methods used throughout academia and industry to produce dendritic cells. [Northwest Biotherapeutics, Inc.] Press Release

St. Jude Children’s Research Hospital Announces Issuance of U.S. Patent for Genetically Modified Human Immune Cells for Cancer Therapy
The United States Patent and Trademark Office awarded St. Jude Children’s Research Hospital U.S. patent number 8,399,645 for St. Jude’s invention of compositions for genetically modifying human immune cells so they can destroy some of the most common forms of cancer in children and adults. [St. Jude Children’s Research Hospital] Press Release

 
POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
EVENTS

NEW RNA Therapeutics
June 5-6, 2013
London, United Kingdom

NEW Montreal International Symposium on Angiogenesis and Metastasis (MISAM-2013)
June 12-14, 2013
Montreal, Canada

Visit
our events page to see a complete list of events in the cancer stem cell community.

JOB OPPORTUNITIES

Faculties in Cancer Biology & Immunotherapy (Huzhou University School of Medicine)

Postdoctoral Scientist (Eli Lilly)

Postdoctoral Position (University of Kentucky College of Medicine)

PhD Studentship Opportunity (University of East Anglia)

Postdoctoral Fellow – Epigenetics (Structural Genomics Consortium at University of Toronto)

Postdoctoral Fellowship – Hematopoietic and Leukemia Stem Cells (Cincinnati Children’s Hospital and Medical Center)

PhD Student (Universitätsklinikum Carl Gustav Carus)

PhD Studentship – Signal Transduction and Cancer Research (Department of Medicine, McGill University)

Stem Cell Program Director (Cancer Treatment Centers of America)


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